中国全科医学Issue(17)：1946-1949,4.DOI:10.3969/j.issn.1007-9572.2014.17.006
糖化血红蛋白诊断糖尿病及糖调节受损截点的研究
HbA 1c Diagnosing Diabetes and Its Cut-off Point for Impaired Glucose Regulation
摘要
Abstract
Backgrounds American Diabetes Association( ADA) recommends glycosylated hemoglobin( HbA1c )≥ 6. 5% as a diagnostic criteria for diabetes mellitus(DM),but it remains to be confirmed whether this standard is applicable to the population in our country. In addition,the hemoglobin concentration differences between people living at different altitudes influence estimated values of HbA1c ,which makes it difficult to formulate diagnostic criteria. Objectives To detect the HbA1c levels of elderly population in Jizhong Plain to explore the optimum value of HbA1c diagnosing DM. Methods A randomized cluster sampling method was used to select 3,168 community residents in 5 central cities in Jizhong plain from June 2011 to Octo-ber 2012 to perform a cross - sectional epidemiological survey. We determined fasting plasma glucose(FPG)and fingertip glu-cose,did oral glucose tolerance test(OGTT)and combined with HbA1c detection. Results The cut - off point of HbA1c diag-nosing DM was 6. 35% ,its sensitivity and specificity were 93. 5% ,87. 2% ,respectively. The cut - off point of HbA1c diagno-sing impaired fasting glucose(IFG)was 5. 75% ,its sensitivity and specificity were 79. 5% ,31. 3% ,respectively. The cut -off point of HbA1c diagnosing impaired glucose tolerance( IGT)was 5. 75% ,its sensitivity and specificity were 85. 4% , 34. 4% ,respectively. Conclusion In plain areas,the DM diagnostic value of HbA1c ,superior to that of single - used FPG or 2 hPG,can be a good indicator for blood sugar level but not for IFG,IGT. OGTT is needed to avoid misdiagnosis.关键词
血红蛋白 A,糖基化/葡糖耐量试验/糖尿病/糖调节受损/糖耐量减退/空腹血糖受损/诊断/平原Key words
Hemoglobin A,glycosylated/Glucose tolerance test/Diabetes mellitus/Impaired glucose regulation/Impaired fasting glucose/Diagnosis/Plain分类
医药卫生引用本文复制引用
张艳丽,孟令荣,马静静,郭淑芹,李志红,张红杰,张云良..糖化血红蛋白诊断糖尿病及糖调节受损截点的研究[J].中国全科医学,2014,(17):1946-1949,4.基金项目
河北省科技支撑计划项目（12277703d）；河北省医学科学研究重点课题计划项目 （）
