中国全科医学Issue(17)：1955-1958,4.DOI:10.3969/j.issn.1007-9572.2014.17.008
甲状腺功能正常的冠心病患者颈动脉内膜中层厚度与血清促甲状腺激素水平的相关性分析
Correlation between Carotid Artery Intima - media Thickness and Serum Thyroid Hormone Level in CHD Patients with Normal Thyroid Function
摘要
Abstract
Objective To explore the relationship between carotid artery intima - media thickness(IMT)and serum thyroid stimulating hormone(TSH)level in coronary artery disease(CHD)patients with normal thyroid function. Methods A total of 223 CHD patients with normal thyroid function hospitalized in the First Affiliated Hospital of Xinjiang Medical University from July 2012 to July 2013 were divided,taking IMT reference value 0. 09 cm as standard,into groups normal IMT(IMT ﹤0. 09 cm,n = 100),thickening IMT(IMT≥0. 09 cm,n = 123),and according to 2002 US NACB recommended analysis TSH value,taking serum TSH observed number percentile P25 (TSH = 1. 35 μU/ ml),P75 (TSH = 2. 57 μU/ ml)as point of con-tact,into groups high TSH(TSH≥ 2. 57 μU/ ml,n = 54),moderate TSH(1. 35 μU/ ml ﹤ TSH ﹤ 2. 57 μU/ ml,n = 109), low TSH(TSH ≤1. 35 μU/ ml,n = 60). Patients′ general clinical data( body height,body mass,BMI)were collected, TG,TC,LDL - C,HDL - C,apolipoprotein A1,apolipoprotein B,serum TSH levels were measured,and the correlation be-tween IMT and TSH level were analyzed. Results The age,BMI,TG,TC,LDL - C,apolipoprotein B,TSH were higher in thickening IMT group than in normal IMT group(P ﹤ 0. 05). There was significant difference in BMI,TG,TC,IMT between groups high,moderate,low TSH(P ﹤ 0. 05);BMI,TG,TC,IMT were higher in high TSH group than in groups moderate, low IMT(P ﹤ 0. 05),TC was higher in moderate group than in low TSH group( P ﹤ 0. 05). Pearson correlation analysis showed that IMT was positively correlated with age,BMI,TG,TC,LDL - C,apolipoprotein B,TSH(r = 0. 245,0. 258, 0. 476,0. 335,0. 218,0. 115,0. 346,respectively,P ﹤ 0. 05);after partial correlation analysis adjusted age,BMI,TG, TC,LDL - C,apolipoprotein B,ITM was still positively correlated with TSH(r = 0. 185,P ﹤ 0. 05). Multiple linear regres-sion analysis showed that age,TG,TSH were independent risk factors influencing IMT( standardized regression coefficient =0. 170,0. 240,0. 377,P ﹤ 0. 05);after adjusted BMI,TC,LDL - C,apolipoprotein B,age,TG,TSH were still inde-pendent risk factors influencing IMT(standardized regression coefficient = 0. 429,0. 241,0. 190,P ﹤ 0. 05). Conclusion In CHD patients with normal thyroid function,IMT is positively correlated with TSH,which may be independent risk factor influ-encing IMT,to provide basis for its clinical research.关键词
甲状腺/促甲状腺激素/颈动脉内膜中层厚度/冠心病Key words
Thyroid gland/Thyrotropin/Carotid intima - media thickness/Coronary disease分类
医药卫生引用本文复制引用
白布加甫·高娃,关婕,高颖..甲状腺功能正常的冠心病患者颈动脉内膜中层厚度与血清促甲状腺激素水平的相关性分析[J].中国全科医学,2014,(17):1955-1958,4.基金项目
新疆维吾尔自治区自然科学基金 （）
