中国全科医学Issue(17)：2003-2007,5.DOI:10.3969/j.issn.1007-9572.2014.17.019
亚低温治疗重型颅脑损伤复温时机的 Meta 分析
Mild Hypothermia for Severe Craniocerebral Injuries:A Meta-analysis of Rewarming Time
摘要
Abstract
Objective To analyze the effects of mild hypothermia therapy(MHT)time on the prognosis and intracra-nial pressure(IP)in patients with severe craniocerebral injuries,to find the best rewarming time after MHT. Methods The Cochrane,PubMed,EMBase,CBM,CNKI,Wangfang Data,VIP database were searched for relevant information and evalua-ted the quality of the enrolled literatures according to Cochrane Reviewer Handbook 5. 2. RevMan 5. 2 software was used to do meta - analysis on the extracted data. Results A total of eight literatures were included in this Meta - anlysis. The mortality rate was lower in MHT group than in normal temperature(NT)group〔RR = 0. 75,95% CI(0. 60,0. 93),P = 0. 007〕. By subgroup analysis,mortality was lower in subgroups 3 ~ 5 d - MHT and MHT - till - normal - IP than in NT group(RR = 0. 68, 0. 65). The prognosis was better in MHT group than in NT group〔RR = 1. 32,95% CI(1. 11,1. 57),P = 0. 002〕. By sub-group analysis,prognosis was better in subgroups 72 h - MHT〔RR = 1. 76,95% CI(1. 23,2. 52),P = 0. 002〕,3 ~ 5 d -MHT〔RR = 1. 41,95% CI(1. 09,1. 82),P = 0. 009〕,MHT - till - normal - IP〔RR = 1. 41,95% CI(1. 15,1. 73),P= 0. 0010〕than in NT group. Conclusion The best MHT rewarming time may be on the 5th day,which needs more high -quality clinical studies for further validation.关键词
低温,人工/颅脑损伤/颅内压/Meta 分析Key words
Hypothermia,induced/Craniocerebral trauma/Intracranial pressure/Meta - analysis分类
医药卫生引用本文复制引用
宋向奇,陈通,付爱军,朱军,李建民,金玉兰,王瑞刚,肖增兵..亚低温治疗重型颅脑损伤复温时机的 Meta 分析[J].中国全科医学,2014,(17):2003-2007,5.基金项目
唐山市科技局指令性课题 （）
