中国全科医学Issue(18)：2090-2095,6.DOI:10.3969/j.issn.1007-9572.2014.18.010
汉族和维吾尔族结直肠癌患者K-ras基因突变情况及影响因素分析
Detection and Analysis on Influencing Factor of K -ras Gene Mutations in Han and Uyghur Patients with Colorectal Cancer
刘超 1郑超 1才层 1穆振诺 1阿丽亚·阿不都卡德尔 1玛依努尔·艾力1
作者信息
- 1. 830054新疆乌鲁木齐市，新疆医科大学第一附属医院肿瘤中心三科
- 折叠
摘要
Abstract
Objective To study the K-ras gene mutations in Han and Uyghur patients with colorectal cancer in Xin-jiang and to compare the K-ras gene mutation rate as well as to analyze influencing factors. Methods 91 cases of paraffin-embedded tissue specimens of colorectal cancer patients(52 cases of Han and 39 cases of Uyghur)admitted to the First Affiliated Hospital of Xinjiang Medical University from January 2010 to March 2013 were collected. K-ras gene mutations in codon 12 and 13 of exon 2 were detected by pyrosequencing. The K-ras gene mutation rate between Han and Uyghur was compared,and uni-variate and multivariate Logistic regression analysis were used to analyze influencing factors for K-ras gene mutation. Results 33 cases(36. 3%)were mutated at K-ras gene. 24 cases(72. 7%)were mutated at codon 12 and 9 cases(27. 3%)were mutated at codon 13,and no case had mutation at both codon 12 and codon 13. The mutation at codon 12 in Uyghur was signifi-cantly higher than in Han(P<0. 05),but the overall mutation rate and mutation rate at codon 13 showed no statistically signifi-cant difference(P>0. 05). The mutation rate of K-ras gene in patients with colorectal cancer had no correlation with sex, age,smoking history,drinking history,tumor location,pathologic type,degree of differentiation,stage,depth of invasion, lymph node metastasis and distant metastasis(P>0. 05). Conclusion K-ras gene mutation rate is high in patients with color-ectal cancer. Mutation rate at codon 12 in Uyghur is higher than in Han. K-ras gene mutation rate in patients has no significant correlation with clinical and pathological features.关键词
结直肠肿瘤/汉族/维吾尔族/基因/突变Key words
Colorectal neoplasms/Han nationality/Uyghur nationality/Genes/Mutation分类
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刘超,郑超,才层,穆振诺,阿丽亚·阿不都卡德尔,玛依努尔·艾力..汉族和维吾尔族结直肠癌患者K-ras基因突变情况及影响因素分析[J].中国全科医学,2014,(18):2090-2095,6.
