中国全科医学Issue(19)：2218-2223,6.DOI:10.3969/j.issn.1007-9572.2014.19.012
急性肺栓塞患者血小板指标的变化及临床意义
The Dynamic Changes of the Platelet Parameters of Patients with Acute Pulmonary Embolism and Its Clinical Signifi-cance
摘要
Abstract
Background Recent studies have demonstrated that platelet activation state occurs in patients with venous thromboembolism. Objective To discuss the changes of platelet parameters in patients with acute pulmonary thromboembolism and the value of prognosis evaluation. Methods The study group was consisted of 128 patients who were confirmed the acute pul-monary embolism in the First Teaching Hospital of Xinjiang Medical University from June 2007 to June 2013. And 130 healthy sub-jects selected at the same time from the hospital physical examination cases as the matched control group,two groups were given physical examination,cardiac ultrasound and biochemical examination. The two groups were detected peripheral blood platelet count(PLT),mean blood platelet volume(MPV)and platelet distribution width(PDW). Based on the result,the researchers analyzed the correlation between platelet index and other observed indexes,dynamically observed the changes of platelet index be-fore treatment,3 months and 6 months after treatment and used multiple logistic regression analysis to determine the influencing factors for pulmonary embolism. Results No significant differences were found in systolic pressure,diastolic pressure,heart rate,hemoglobin,mean corpuscular hemoglobin,mean corpuscular hemoglobin concentration,PLT,PDW,triglyceride,total cholesterol between the control group and the research group(P﹥0. 05);MPV differences between two groups were statistically significant(P﹤0. 05). PLT and MPV differences among pulmonary embolism patients with different degrees of embolization were significant(P﹤0. 05);PLT in low risk group and medium risk group was highter than that in high risk group and the case of MPV was just the opposite(P﹤0. 05). No significant difference of PDW was found between the three groups(P﹥0. 05). In the control group,the correlation between MPV and PDW was positive(r=0. 335,P=0. 000),no linear correlation between PDW and PLT(r= -0. 034,P=0. 700)and no linear correlation between PLT and MPV(r= -0. 125,P=0. 161). In the study group,the correlation between MPV and PDW was positive(r=0. 212,P=0. 016);PDW was negatively correlated with PLT(r= -0. 292,P=0. 001)and PLT was negatively correlated with MPV(r= -0. 271,P=0. 002). There were no signifi-cant difference in PLT,MPV,PDW levels of the 8 cases of patients before treatment,3 months,and 6 months after treatment (F=0. 894,0. 934,0. 132,P =0. 386,0. 416,0. 877). Multiple Logistic regression analysis showed that age,smoking history,MPV and PDW had regression relation with pulmonary embolism(P﹤0. 05). Conclusion MPV and PLT have certain clinical significance in judging the severity of embolism,but the changes of MPV and PLT within the short time( within 6 months after treatment)can't simply be used to assess the recovery degree of the patients.关键词
肺栓塞/血小板计数/血小板平均体积/血小板分布宽度Key words
Pulmonary embolism/Platelet count/Mean platelet volume/Platelet distribution width分类
医药卫生引用本文复制引用
陈嵩,张莹,戴月梅,西艾木西卡买尔·艾合买提,王在义,林勇,刘晖..急性肺栓塞患者血小板指标的变化及临床意义[J].中国全科医学,2014,(19):2218-2223,6.基金项目
国家“十二五”科技支撑计划课题---肺栓塞防治网络建设与临床诊治关键技术研究 （）
