Abstract
Objective Toinvestigatethelevelsofmalondialdehyde(mDA),totalantioxidantcapacity(T-Aoc), 25-hydroxy vitamin D3〔25-(OH)D3〕and their relationship to insulin resistance(IR)in obese young men with normal glucosetolerance(NGT).Methods Eighty-oneyoungmenwithNGThavingphysicalexaminationsintheFirstHospitalof Qinhuangdao from November 2012 to February 2013 were divided,taking WC≥90 cm as diagnostic criteria of abdominal-obe-sity,into groups obesity(n=39),control(n=42). SBP,DBP,WC,BmI,FPG,FINS,TG,TC,HDL-C,LDL-C,mDA,T-Aoc,25-( OH) D3 ,2 hPG,2 hINS were determined. Pearson linear correlation analysis and multiple linear regression analysis were used to analyze the relationship of mDA,T-Aoc,25-(OH)D3 to insulin resistance index (HOmA-IR).Results TherewasnosignificantdifferenceinlevelsofTC,LDL-C,FPG,2hPGbetween2groups(P﹥0. 05). WC,BmI,SBP,DBP,TG,FINS,2 hINS,mDA,HOmA-IR were higher in obesity group than in control group, HDL-C,T-Aoc,25-(OH)D3 lower(P﹤0. 05). By Pearson linear correlation analysis,T-Aoc was negatively corre-lated with BmI,WC,DBP,HOmA-IR(r= -0. 451,-0. 472,-0. 430,-0. 462,P﹤0. 05),positively with HDL-C,25-(OH)D3(r=0. 474、0. 472,P ﹤0. 05);mDA was positively correlated with BmI,WC,2 hPG,HOmA-IR (r=0. 402,0. 495,0. 504,0. 566,P ﹤0. 05),negatively with 25-(OH)D3(r = -0. 459,P ﹤0. 05). By multiple linear regression analysis,the correlation between 25-( OH) D3 ,mDA and HOmA-IR was the strongest,HOmA-IR was negatively correlated with 25-(OH)D3,positively with mDA(standardized partial regression coefficient= -0. 383,0. 356, P﹤0.05).Conclusion mDAincreases,T-AocandvitaminDdecreaseinabdominal-obesityyoungmenwithNGT,mDA and vitamin D are the main influencing factors of IR,and provides a reference value for future clinical research.关键词
腹型肥胖/丙二醛/抗氧化能力/维生素D/氧化应激/胰岛素抵抗Key words
Abdominalobesity/malondialdehyde/Antioxidant/VitaminD/Oxidativestress/Insulinresistance分类
医药卫生
