中国全科医学Issue(20)：2345-2348,2352,5.DOI:10.3969/j.issn.1007-9572.2014.20.014
抗血小板治疗对老年人血小板功能的影响及其环氧化酶1和环氧化酶2基因多态性研究
Changes of Platelet Function after Antiplatelet Therapy and Single Nucleotide Polymorphism of COX-1 and COX-2 in Elderly Patients
摘要
Abstract
Objective Toinvestigatetheimpactsofantiplatelettherapy(APT)onplateletfunctionandthesingle nucleotide polymorphism( SNP) of COX-1 and COX-2 in elderly patients,to provide individualized intervention guidance for clinicalAPT.Methods FromJanuary2011toDecember2012,atotalof114patients(agedover60years)havingtakenba-yaspirin over 1 year were enrolled in this study,including 55 with thrombotic high-risk factors( group A),59 who ever had ar-tery thrombosis incidence( group B),another 55 healthy subjects enrolled as control group. Blood platelet count( PLT),mean platelet volume(mPV),thromboelastogram(TEG-mA),arachidonic acid-induced platelet inhibition rate(TEG-AA), COX-1-1676A﹥GandCOX-2-765G﹥CSNPweredeterminedin3groups.Results Therewasnosignificantdifference in PLT in 3 groups(P﹥0. 05). mPV,TEG-mA were greater in group B than in groups A,control(P﹤0. 05). All partici-pants were divided,according to TEG-AA,into groups non-aspirin-sensitive(NAS,n=66),aspirin-sensitive(AS,n=103);there were significant differences in COX-1 -1676A ﹥G genotype and allele frequencies between 2 groups( P ﹤0.05),therewasnoinCOX-2-765G﹥Cgenotypeandallelefrequencies(P﹥0.05).Conclusion Increasedactivityof PLT,a major cause for thrombogenesis,has aspirin resistance( AR) in elderly patients having APT due to thrombotic high-risk factors or ever having artery thrombosis incidence. COX-1-1676A﹥G SNP may be related to AR,COX-2-765G﹥G SNP may not.关键词
血小板聚集抑制剂/多态性,单核苷酸/血栓弹力描记术/血小板功能/老年人Key words
Plateletaggregationinhibitors/Polymorphism,singlenucleotide/Thrombelastography/Plateletfunc-tion/Aged分类
医药卫生引用本文复制引用
梁辉,黄洁杰,周熙琳,王文安..抗血小板治疗对老年人血小板功能的影响及其环氧化酶1和环氧化酶2基因多态性研究[J].中国全科医学,2014,(20):2345-2348,2352,5.基金项目
上海市崇明县科委课题 （）
