|国家科技期刊平台
| 注册
首页|期刊导航|中国全科医学|整合素和金属蛋白酶域33基因 V4多态性与支气管哮喘易患性关系的 Meta分析

整合素和金属蛋白酶域33基因 V4多态性与支气管哮喘易患性关系的 Meta分析

张林 张云 张智峰 张文涵 方春晓 于丽艳

中国全科医学Issue(21)：2472-2477,6.
✕
中国全科医学Issue(21)：2472-2477,6.DOI:10.3969/j.issn.1007-9572.2014.21.013

整合素和金属蛋白酶域33基因 V4多态性与支气管哮喘易患性关系的 Meta分析

V4 Polymorphisms in the ADAM33 Gene and Liability of Bronchial Asthma：A Meta-analysis on Their Relationship

张林 1张云 2张智峰 3张文涵 1方春晓 1于丽艳1

作者信息

  • 1. 116011 辽宁省大连市，大连医科大学附属第一医院呼吸内科
  • 2. 大连大学附属中山医院
  • 3. 116011 辽宁省大连市，大连医科大学附属第一医院消化内科
  • 折叠

摘要

Abstract

ObjectiveToevaluatetherelationshipbetweenV4(rs2787094G>C)polymorphismsinadisintegrin and metalloproteinase 33 (ADAM33) gene and liability of bronchial asthma .Methods Relevant studies were searched for in CBM, VIP, Wanfang, CNKI, PubMed, EMBase, Google Scholar, and Web of Science databases from their inception to Au-gust 2013.Data was collected and extracted by two researchers , and Stata 12.0 software was used to performed a Meta -analy-sis.Results A total of 8 literatures of randomized controlled studies were included , including 2 128 asthma patients and 3 134 healthy controls.By Meta-analysis, in allele and dominant models, ADAM33 gene V4 polymorphism was related to liability of bronchial asthma 〔G vs.C: OR=1.58, 95%CI (1.14, 2.18), P=0.006; GG+GC vs.CC: OR=1.42, 95%CI (1.25, 1.60), P=0.000〕.By subgroup analysis, when controls were general people , in allele and dominant models, ADAM33 gene V4 polymorphism was related to liability of bronchial asthma 〔G vs.C: OR=1.58, 95%CI (1.06, 2.35), P=0.024; GG+GC vs.CC: OR=1.40, 95%CI (1.22, 1.60), P=0.000〕; When control group were from hospital , in allele models, ADAM33 gene V4 polymorphism was not related to liability of bronchial asthma 〔OR=1.57, 95%CI (0.73, 3.37), P=0.244〕, and in dominant models , ADAM33 gene V4 polymorphism was related to liability of bronchial asthma 〔OR=1.53, 95%CI ( 1.12, 2.08 ), P =0.000〕. By polymerase chain reaction - restricted fragment length polymorphisms ( PCR-RFLP) , in allele and dominant models , ADAM33 gene V4 polymorphism was related to liability of bronchial asthma 〔G vs.C: OR=2.21, 95%CI (1.44, 3.40), P =0.001; GG +GC vs.CC: OR =2.29, 95%CI (1.88, 2.78), P =0.000〕.By other detection methods , in allele and dominant models , ADAM33 gene V4 polymorphism was not related to liabil-ity of bronchial asthma 〔G vs.C: OR=1.07, 95%CI (0.94, 1.21), P=0.314; GG+GC vs.CC: OR=1.02, 95%CI (0.87, 1.20), P=0.769〕.Conclusion ADAM33 gene V4 polymorphism, probably related to liability of bronchial asthma , can be used as a molecular marker for early diagnosis of bronchial asthma .

关键词

哮喘/多态性,单核苷酸/Meta分析/整合素和金属蛋白酶域33

Key words

Asthma/Polymorphism,singlenucleotide/Meta-analysis/ADAM33

分类

医药卫生

引用本文复制引用

张林,张云,张智峰,张文涵,方春晓,于丽艳..整合素和金属蛋白酶域33基因 V4多态性与支气管哮喘易患性关系的 Meta分析[J].中国全科医学,2014,(21):2472-2477,6.

中国全科医学

OA北大核心CSCDCSTPCD

1007-9572

访问量0
|
下载量0
段落导航相关论文