中国全科医学Issue(21)：2510-2512,3.DOI:10.3969/j.issn.1007-9572.2014.21.023
三分之一常规剂量光敏剂维替泊芬联合光动力疗法治疗急性中心性浆液性脉络膜视网膜病变多中心临床效果观察
The Clinical Effect of Photodynamic Therapy with 1/3 Conventional-dose Verteporfin on Acute Central Serous Chori-oretinopathy
党维华 1于沛涛 2刘宁宁 3王冠晶 4吕玲1
作者信息
- 1. 110002辽宁省沈阳市，沈阳医学院沈洲医院眼科
- 2. 北京大学医学部基础医学院
- 3. 中国医科大学第一临床学院眼科
- 4. 沈阳市第四人民医院眼科
- 折叠
摘要
Abstract
ObjectiveToobservethetherapeuticeffectandsafetyofphotodynamictherapy(PDT)with1/3conven-tional-doseverteporfinonacutecentralserouschorioretinopathy(CSC).Methods 90patients(90eyes)whowerediagnosed as acute CSC in Shenzhou Hospital Affiliated to Shenyang Medical College , the First Affiliated Hospital of China Medical Univer-sity, and Shenyang Fourth People′s Hospital from October 2011 to October 2012, were selected as study subjects .All patients ac-cepted intravenous injection of 1/3 conventional-dose verteporfin (2 mg/m2 ), 5 min later, patients received laser irradiation (689 nm) for 83 s.The follow -up time point was 1 week, 1, 3, 6 months after treatment.The best corrected visual acuity (BCVA), area of subretinal fluid and central fovea thichness (CFT) were compared before and after treatment , and the adverse reactions were recorded .Results The BCVA after treatment was significantly higher than that before treatment , area of subretinal fluid after treatment was significantly smaller than that before treatment , CFT after treatment was significantly thinner than that be-fore treatment (all P<0.05) .The BCVA, area of subretinal fluid and CFT 1 month after treatment were much better those be-fore treatment, the BCVA and area of subretinal fluid and CFT kept stability from 1 month after treatment to 6 months after treat-ment, no adverse reaction occurred within this period .Conclusion PDT with 1/3 conventional-dose verteporfin for acute CSC could improve symptoms , improve and maintain visual acuity , prevent or reduce the leakage from choroidal vascular , promote anatomical reposition of retinal , and have no obvious adverse reactions .关键词
视网膜疾病/光敏感药/维替泊芬/光化学疗法Key words
Retinaldiseases/Photosensitizingagents/Verteporfin/Photochemotherapy分类
医药卫生引用本文复制引用
党维华,于沛涛,刘宁宁,王冠晶,吕玲..三分之一常规剂量光敏剂维替泊芬联合光动力疗法治疗急性中心性浆液性脉络膜视网膜病变多中心临床效果观察[J].中国全科医学,2014,(21):2510-2512,3.
