摘要
Abstract
ObjectiveToinvestigatethedetectionofcerebralmicrobleeds(CMBs)bysusceptibilityweightedima-ging(SWI),andinfluenceofCMBsoncognitivefunction.Methods 50patientswhowereactuallydiagnosedwithCMBsby SWI in inpatient and outpatient departments of neurology , Shaoxing People′s Hospital from January 2012 to August 2013, were selected as CMBs group , during the same period , while 44 sex-, age-and education level -matched physical examination people who were not found to have CMBs by SWI , were selected as control group , their cognitive function was evaluated by MoCA rating scale , MoCA score were compared between the two groups and the cognitive dysfunction caused by CMBs of different regions and different degrees .Results SWI imaging features of CMBs were sharply marginated small round low signal images in brain parenchyma.The total MoCA scores, visuospatial skills and execution function scores , nomenclature scores, attention scores, language scores, abstracting scores, memory scores and directive force scores in CMBs group were significantly lower than those in control group ( P<0.05 ) .The total MoCA scores , visuospatial skills and execution function scores , abstracting scores and memory scores in mild CMBs group , moderate CMBs group and severe CMBs group were significantly lower than those in control group; Nomenclature scores , attention scores and language scores in moderate CMBs group and severe CMBs group were significantly lower than those in control group ( P<0.05 ) .The total MoCA scores , attention scores , abstracting scores and memory scores in moderate CMBs group and severe CMBs group were significantly lower than those in mild CMBs group ;Visuospatial skills and execution function scores and language scores in severe CMBs group were significantly lower than those in mild CMBs group (P<0.05) .The total MoCA scores, visuospatial skills and execution function scores , attention scores, lan-guage scores and memory scores in severe CMBs group were significantly lower than those in moderate CMBs group (P<0.05). According to Spearman correlation analysis results , the CMBs number was negatively correlated with total MoCA scores , visuo-spatial skills and execution function scores , attention scores , language scores , abstracting scores and memory scores ( P <0.05); Cortico-subcortical CMBs was negatively correlated with total MoCA scores , visuospatial skills and execution function scores, attention scores, language scores and memory scores (P<0.05); Basal ganglia and thalamus CMBs was negatively cor-related with total MoCA scores and language scores (P<0.05); Brainstem and subtentorial CMBs was negatively correlated with total Mo CA scores and visuospatial skills and execution function scores ( P <0.05 ) .Conclusion SWI can clearly display CMBs, CMBs can cause cognitive dysfunction , and the characteristics of cognitive dysfunction varies by the region and degree of CMBs.关键词
脑出血/磁共振成像/认知/蒙特利尔认知评估量表Key words
Cerebralhemorrhage/Magneticresonanceimaging/Cognition/Montrealcognitiveassessment分类
医药卫生
