中国全科医学Issue(24)：2806-2809,4.DOI:10.3969/j.issn.1007-9572.2014.24.006
高血压脑出血破入脑室患者血清皮质醇水平变化及其与预后关系的研究
Changes of Serum Cortisol and Its Clinic Significance in Patients with Intraventricular Hemorrhage Secondary to Cere-bral Hemorrhage
摘要
Abstract
Objective To explore the changes of serum cortisol and the relationship between the changes and prognosis in patients with intraventricular hemorrhage secondary to cerebral hemorrhage. Methods 42 patients with intraventricular hemor-rhage secondary to cerebral hemorrhage admitted to the General Hospital of Tianjin Medical University from September 2011 to De-cember 2012 were selected. The fasting serum levels of cortisol were measured at seven oˊclock on 1 d,2 d,3 d,5 d,7 d and 14 d. The patients were divided into three groups based on the serum levels of cortisol on the first day of onset:decreasing group (6 cases),normal group(15 cases)and increasing group(21 cases). The Glasgow coma scale( GCS)score on admission, Graeb score,amount of bleeding,lung infection rate,hospital stay and the Glasgrow outcome scale( GOS)score three months after discharge were observed. Results The serum cortisol levels at different time of the three groups all showed statistically sig-nificant differences(Finter-group =584. 40,Ftime =10. 24,Finteraction =6. 78,P <0. 000 1). The decreasing group and normal group,the decreasing group and increasing group and the normal group and increasing group( except 14 d)showed statistically significant differences pairwise(P<0. 05). The GCS score,Graeb score and amount of bleeding in the three groups on admis-sion showed statistically significant differences(P<0. 05). Among them,the GCS score in decreasing group was lower than the normal group and increasing group,but the Graeb score and amount of bleeding were higher than the normal group and increasing group(P<0. 05). The GCS score in normal group was higher than the increasing group,but the Graeb score and amount of bleeding were lower than the increasing group(P<0. 05). The lung infection rate,hospital stay and GOS score three months after discharge in the three groups all showed statistically significant differences ( P<0. 05 ) . Compared with the normal group and increasing group,the decreasing group had higher rate of lung infection,longer hospital stay and lower GOS score( P<0. 05 ). Conclusion The changes of serum cortisol level in patients with intraventricular hemorrhage secondary to cerebral hem-orrhage is related to the disease severity on admission. The patients with decreased serum cortisol level have the worst prognosis.关键词
颅内出血,高血压性/皮质醇/预后/格拉斯哥昏迷量表Key words
Intracranial hemorrhage,hypertensive/Cortisol/Prognosis/Glasgow coma scale分类
医药卫生引用本文复制引用
刘晓峰,金卫篷,张建宁..高血压脑出血破入脑室患者血清皮质醇水平变化及其与预后关系的研究[J].中国全科医学,2014,(24):2806-2809,4.基金项目
天津市卫生局科技基金资助项目 （）
