摘要
Abstract
Objective To investigate the clinical efficacy of sustained low-efficiency daily diafiltration( SLEDD-f) combined with hemoperfusion( HP)in treatment of sepsis-induced acute kidney injury. Methods A total of 43 patients with sepsis-induced acute kidney injury who received CRRT or SLEDD-f combined with HP treatment in department of emergency, the First Hospital Affiliated to Nanhua University from January 2008 to December 2011,were divided into CRRT group( C group,21 cases)and LEDD-f combined with HP treatment group( T group,22 cases)according to various blood purification methods. APCHEⅡ score,mean arterial pressure( MAP),dopamine( DA)dose,levels of serum creatinine( Scr),hemo-globin(Hb),Albumin(Alb),white blood cell count(WBC),high-sensitivity C-reactive protein(hs-CRP),serum IL-6,IL-10 and tumor necrosis factor-α(TNF-α)before and after treatment were compared between two groups. The com-plication rates,30 days survival rates,and the duration of ICU stays were compared between two groups. Results There was no statistical difference in APCHEⅡ score,MAP,DA dose,levels of Scr,Hb,Alb,WBC,hs-CRP,IL-6,IL-10 and TNF-α before treatment between two groups(P .0. 05). There were significant differences in MAP,DA dose,levels of Scr, WBC,hs-CRP,IL-6,IL-10 and TNF-α after treatment between two groups(P<0. 05). Patients in two groups had no serious complications during therapy period. The 30 days survival rate in group C〔47. 6%(10/21)〕was significantly lower than that〔77. 3%(17/22)〕in group T(χ2 =4. 044,P<0. 05). The duration of ICU stays in group C〔(16. 3 ± 5. 2) d〕was significantly longer than that in group T〔(11. 2 ± 3. 5)d〕(t=3. 789,P<0. 05). Conclusion The clinical efficacy of SLEDD-f combined with HP is better than CRRT in the treatment of sepsis-induced acute kidney injury,and 30 days survival rate is higher,duration of ICU stays is shorter,SLEDD-f combined with HP therapy is a new treatment program for patients with sepsis-induced acute kidney injury.关键词
血液透析滤过/血液灌流/脓毒症/急性肾损伤Key words
Hemodiafiltration/Hemoperfusion/Sepsis/Acute kidney injury分类
医药卫生
