摘要
Abstract
Objective Toinvestigatetheriskfactorsofcryptococcusneoformansmeningitisandprovidefurtherevi-denceforetiology.Methods Thestratifiedrandomsamplingmethodwasused.First,wehadchosen2countriesand1districtin Jingdezhen city based on the stratified geographical position and second,we had chosen citizens from 2 villages in the 2 countries and 1 district according to certain proportion and finally 8 348 citizens were brought into our research. The cohort was followed for two years from July,2O11 to July,2O13. We used the 1:1 matching prospective nested case-control study method to explore the relatedfactorsofcryptococcusneoformansmeningitisandLogisticregressionmodeltodeterminetheriskfactors.Results Until July,2O13,63 cases of cryptococcus neoformans meningitis were found in the follow-up cohort including 38 males and 25 fe-males,aged 5~64 with a median age of 39. 5(case group). According to matching principle,another 63 citizen without the case were selected including 38 males and 25 females,aged 4~67 with a median age of 38. 7(control group). Single factor a-nalysis of the 1:1 matching material indicated that educational background,single,unemployed,dove bird feces,diabetes mel-litus,AIDS,contacting with dead animals factors were into the regression equation(P<O. O5). Multiple factors logistic regres-sion analysis showed that single(OR=1. 3O8),unemployed(OR=1. O32),diabetes mellitus(OR=2. O5O),diabetes mel-litus,AIDS(OR=3. 87O),contacted the dove bird feces(OR=3. O82),contacting with dead animals(OR=2. 812)were the risk factors of cryptococcus neoformans meningitis and educational background was the protective factor(OR=O. 9O8). Con-clusion Single,unemployed,diabetesmellitus,AIDS,onceexposedtothedovebirdfecesandrotofbiomassaretheriskfac-tors related to cryptococcal meningitis. The research findings provide further evidence for the etiology of cryptococcal meningitis.关键词
新型隐球菌性脑膜炎/危险因素/前瞻性巢式病例对照研究Key words
Cryptococcus neoformans meningitis/Risk factors/Prospective nested case - control study分类
医药卫生
