中国全科医学Issue(27)：3242-3244,3.DOI:10.3969/j.issn.1007-9572.2014.27.021
三维适型放射治疗结合替莫唑胺治疗弥漫性脑干胶质瘤疗效分析
Efficacy of Three - dimensional ℅onformal Radiotherapy ℅ombined with Temozolomide in the Treatment of Diffuse Brainstem Glioma
岳向勇 1武江 1梁传栋 1邱刚 1陈尧 1郑杰 1李文玲 1康进生 1董长征1
作者信息
- 1. 050051 河北省石家庄市，河北省人民医院神经外二科，肿瘤二科
- 折叠
摘要
Abstract
Objective Toinvestigatetheefficacyofthree-dimensionalconformalradiotherapycombinedwithtemozo-lomideinthetreatmentofdiffusebrainstemglioma.Methods Theclinicaldataof21brainstemgliomacasesinourhospitalfrom January 2006 to January 2010 were retrospectively analyzed. They were randomly divided into three-dimensional conformal radio-therapy group(9 cases)and radiotherapy combined with temozolomide chemotherapy group(12 cases). KPS scores were used to evaluate the quality of life. Survival time and adverse effect( the start of treatment until death)were determined through follow-up.Results Beforetreatment,therewasnosignificantdifferenceinKPSscoresbetweenradiotherapygroupandchemotherapy and radiotherapy group〔(68. 3 ±5. 0)vs. (69. 2±6. 3),t=0. 053,P>0. 05〕. After six months treatment,the KPS of concurrent chemotherapy and radiotherapy group was significantly higher than the KPS of radiotherapy group〔(76. 7±13. 0)vs. (66. 7 ±24. 5),t=5. 039,P<0. 05〕. The adverse effects of chemotherapy were mainly nausea and vomit,as well as occa-sional headache,rash and hypocytosis,ⅠtoⅡlevel. The adverse effects were alleviated after treatment. No adverse effect higher than level Ⅲ was found. During the three years follow up,18 cases died and 3 cases survived. The median survival time of the two groups was 19 months and 26 months respectively,showing statistically significant difference(P=0. 009). The one-year and two-year survival rate of radiotherapy group was 77. 8% and 11. 1% respectively,while the number for the concurrent chemo-therapyandradiotherapygroupwas83.3%and50.0%.℅onclusion Three-dimensionalconformalradiotherapycombinedwith temozolomide chemotherapy can significantly improve the life quality of brainstem low-grade glioma( diffuse)patients and pro-long their survival,with a good application prospect.关键词
神经胶质瘤/脑干/放射疗法,适形/替莫唑胺Key words
Glioma/Brainstem/Radiotherapy,conformal/Temozolomide分类
医药卫生引用本文复制引用
岳向勇,武江,梁传栋,邱刚,陈尧,郑杰,李文玲,康进生,董长征..三维适型放射治疗结合替莫唑胺治疗弥漫性脑干胶质瘤疗效分析[J].中国全科医学,2014,(27):3242-3244,3.
