中国全科医学Issue(29)：3439-3441,3.DOI:10.3969/j.issn.1007-9572.2014.29.009
吸烟与慢性阻塞性肺疾病患者胰岛素抵抗的相关性研究
Smoking and Insulin Resistance:A Correlation Study in COpD patients
薛旗山 1闫春良 1雷芸 1聂晓莉 1张慧娟 1任冠军1
作者信息
- 1. 100076北京市，北京航天总医院呼吸内科
- 折叠
摘要
Abstract
Objective To investigate the relationship between smoking and insulin resistance( IR)in patients with chronic obstructive pulmonary disease( COPD). Methods A total of 114 COPD patients who visited Beijing Aerospace General Hospital from Januray 2012 to May 2013 were divided,according to smoking history,into groups smoking(n=75)and non-smoking(n=39). The smoking group were subdivided,according to smoking index,into subgroups≥600 cigarettes/year and<600 cigarettes/year. Twenty -six healthy subjects who did not smoke were enrolled as control group. We determined lung function and fasting blood glucose( FBG),C -reactive protein( CRP),fasting insulin( FINS),triglyceride( TG),total cholesterol( TC),urinary microalbumin ( MALB ) and calculated insulin resistance index ( HOMA - IR ). Results The FEV1%,FEV1/FVC were lower in smoking group than in non-smoking group,lower in groups smoking,non-smoking than in control group,the difference was significant(P<0. 05). CRP,TG,MALB were higher in smoking group than in non-smoking group,higher in groups smoking,non -smoking than in control group(P <0. 05). There was difference in FBG, FINS,HOMA-IR and IR incidence between 2 subgroups(P<0. 05),and higher in two subgroups than in groups control and non-smoking(P<0. 05). Conclusion Smoking,associated with IR,is a potential risk factor for COPD IR.关键词
肺疾病,慢性阻塞性/吸烟/胰岛素抵抗Key words
Pulmonary disease,chronic obstructive/Smoking/Insulin resistance分类
医药卫生引用本文复制引用
薛旗山,闫春良,雷芸,聂晓莉,张慧娟,任冠军..吸烟与慢性阻塞性肺疾病患者胰岛素抵抗的相关性研究[J].中国全科医学,2014,(29):3439-3441,3.
