Abstract
Objective To explore the preventive effects of Xinmailong injection on anthracyclines induced cardiac tox-icity. Methods Sixty malignant tumor patients in People's Hospital of Hebei Province from April to December 2013 were divided randomly into groups therapy,control,30 in each. Control group were given only anthracycline chemotherapy,therapy group combined with Xinmailong injection,21 d as a therapeutic cycle,altogether 6 cycles. Underwent echocardiogranphy left ventric-ular internal diameter at end-diastole( LVIDD),left ventricular internal end-systolic dimension( LVISD),early and late diastolic filling velocity ratio( E/A),left ventricular ejection fraction( LVEF),ECG〔non-specific ST-T segment and T wave changes,QRS low voltage and vatious arrhythmias( proiosystole,tachycardia,atrioventricular block,etc. )〕and deter-mined serum cardiac troponin I( cTnI)level before treatment,after 3,6 treatment cycles. Results 2 patients in control group,1 in therapy group died due to tumor progression. There were 28 cases in control group,29 in therapy group after exclu-ding the above cases. There was significant difference in LVEF,E/A,LVIDD,LVISD between 2 groups before therapy,after 3,6 therapy cycles(P<0. 05). In group comparison,there was no difference in LVEF,E/A,LVIDD,LIVSD before treat-ment(P>0. 05);there was in E/A,LVIDD,LVISD between 2 groups after a cycles(P<0. 05). In intra-group compari-son,LVIDD,LVISD were higher after 6 cycles than before treatment in control group(P<0. 05). In control group,no pa-tients had ECG abnormalities before treatment,10 had after 3 treatment cycles(35. 7%),18 had after 6 cycles(64. 3%), and in therapy group,0,4(13. 8%),5(17. 2%),respectively. There was no significant difference in ECG abnormality between 2 groups after 3 cycles(χ2 =3. 695,P=0. 055);there was after 6 cycles(χ2 =13. 099,P=0. 000). In control group,ECG abnormality was lower before treatment than after 3,6 treatment cycles(χ2 =12. 174,25. 526,P =0. 000, 0. 000),lower after 3 cycles than after 6 cycles(χ2 =4. 571,P=0. 033);in therapy group,ECG abnormality was lower be-fore treatment than after 3,6 cycles(χ2 =4. 29,5. 472,P=0. 035,0. 019). There was difference in serum cTnI between 2 groups before treatment and after 3,6 cycles(P <0. 05). In group comparison,there was no difference in cTnI between 2 groups before treatment(P>0. 05);there was after 3,6 treatment cycles(P<0. 05). In intra-group comparison,cTnI was higher after 3,6 cycles than before treatment(P<0. 05). Conclusion Xinmailong injection can reduce anthracycline induced cardiac toxicity,enhance patients' tolerance to anthracycline chemotherapy. It is of some preventive effects on anthracycline chemotherapy-induced cardiotoxicity.关键词
心脉隆注射液/蒽环类药物/心脏毒性/药物预防Key words
Xinmailong injection/Anthracyclines/Cardiac toxicity/Chemoprophylaxis分类
医药卫生
