中国全科医学Issue(31)：3720-3723,4.DOI:10.3969/j.issn.1007-9572.2014.31.016
前列地尔对合并糖尿病的冠心病患者介入治疗中造影剂肾病的预防作用研究
The Preventive Effect of Alprostadil on Contrast Nephropathy among the Patients with Coronary Artery Disease Compli-cated with Diabetes in the Interventional Therapy
钟思干 1杨飞 1陈爱文 1刘凌 1廖火城 1肖纯 1姚筱1
作者信息
- 1. 516002 广东省惠州市第三人民医院心内科
- 折叠
摘要
Abstract
Objective To explore the preventive effect of alprostadil in the interventional therapy on contrast nephrop-athy among the patients with coronary artery disease complicated with diabetes. Methods 100 patients with diabetes and coronary artery disease who were admitted in our hospital from January,2012 to July,2013 and scheduled for interventional therapy were randomly divided into observe group(50),receiving additional alprostadil and the control group(50),receiving hydration therapy. The incidence of contrast nephropathy rate,change of vascular endothelium and renal function before and after angiogra-phy,and prognosis between the two groups were compared. Results (1)one case in observe group and eight cases in control group suffered contrast nephropathy and the incidence was 2. 00% and16. 00% respectively,with significant difference( P <0. 05);(2)Before angiography,no significant difference of blood urea,Urine β2 - microglobulin and serum creatinine between the two groups was found;72h after angiography,the difference of blood urea and Urineβ2 - microglobulin was significant be-tween the two groups and from that before angiography(P < 0. 05);the difference of serum creatinine in control group was signif-icant compared with that before angiography(P < 0. 05). (3)The difference of nitric oxide,nitric oxide synthase and endothe-lin 1 between the two groups was not significant(P > 0. 05);72h after angiography,the difference was significant between the two groups and compared with that after angiography( P < 0. 05). (4)13(26. 0% ) and in control 4(8. 0% ) had poor prognosis,with significant difference(P < 0. 05). Conclusion Alprostadil in the interventional therapy can have a satisfactory effect on the prevention of contrast nephropathy among the patients with diabetes and coronary artery disease and on the protection of vascular endothelium and renal function,with a higher prognostic level.关键词
前列地尔/糖尿病/冠心病/介入治疗/造影剂肾病Key words
Alprostadil/Diabetes mellitus/Coronary artery disease/Interventional therapy/Contrast nephropathy分类
医药卫生引用本文复制引用
钟思干,杨飞,陈爱文,刘凌,廖火城,肖纯,姚筱..前列地尔对合并糖尿病的冠心病患者介入治疗中造影剂肾病的预防作用研究[J].中国全科医学,2014,(31):3720-3723,4.
