中国全科医学Issue(32)：3855-3859,5.DOI:10.3969/j.issn.1007-9572.2014.32.019
MTHFR基因677C>T多态性与慢性肾衰竭血液透析患者心血管疾病易患性关联的Meta分析
Correlations of MTHFR 677C > T Polymorphism with Cardiovascular Disease in Chronic Hemodialysis Patients:A Meta- Analysis
摘要
Abstract
Objective This meta - analysis was conducted to evaluate the correlations of a common polymorphism (677C > T)in the methylenetetrahydrofolate reductase(MTHFR)gene with the risk of cardiovascular disease(CVD)in chronic Hemodialysis(HD)patients. Methods The Web of Science(1945-2013),the Cochrane Library Database( Issue 12, 2013),MEDLINE(1966-2013),EMBASE(1980-2013),CINAHL(1982-2013)and the Chinese Biomedical Data-base(CBM)(1982-2013)were searched for relevant literatures,Stata 12. 0 software was used to perform Meta analysis and calculated odds ratio(OD)and its 95% confidence interval(95% CI). Results A total of 8 cohort studies that met all inclu-sion criteria were included in this meta - analysis,including 2 292 chronic HD patients. Meta analysis showed that MTHFR gene 677C > T polymorphism increased the CVD risks of HD patients〔 TT vs. CC:OR = 2. 75,95% CI(1. 35,5. 59),P =0. 005;CT + TT vs. CC:OR = 1. 39,95% CI(1. 09,1. 78),P = 0. 008;TT vs. CC + CT:OR = 2. 52,95% CI(1. 25, 5. 09),P = 0. 010〕. Further ethnicity subgroup analysis suggested that MTHFR 677C > T polymorphism was associated with the incidence of CVD in chronic HD Asians〔TT vs. CC:OR = 3. 38,95% CI(1. 11,10. 28),P = 0. 032;CT + TT vs. CC:OR = 1. 44,95% CI(1. 05,1. 97),P = 0. 022〕,but not in HD Africans and Caucasians(P > 0. 05). Conclusion The findings provide empirical evidence that MEHFR 677C > T polymorphism may contribute to the development of CVD in chronic HD patients,especially among Asians.关键词
亚甲基四氢叶酸还原酶/基因/多态性,单核苷酸/血液透析/心血管疾病/Meta 分析Key words
Methylenetetrahydrofolate reductass/Genes/Polymorphism,single nucleotide/Hemodialysis/Cardio-vascular disease/Meta - analysis分类
医药卫生引用本文复制引用
高显会,张国毅,王莹,张慧影..MTHFR基因677C>T多态性与慢性肾衰竭血液透析患者心血管疾病易患性关联的Meta分析[J].中国全科医学,2014,(32):3855-3859,5.基金项目
辽宁省教育厅科研资助项目 （）
