摘要
Abstract
Objective To detect the levels of plasma hyaluronic acid,procollagen Ⅲ,collagen Ⅳ and laminin and to investigate the relationship between OSAHS and hepatic fibrosis. Methods 52 inpatients and outpatients admitted to our hospital from December 2010 to June 2013 were selected. Based on the BMI,the patients were divided into obesity + OSAHS group(27 cases),normal BMI + OSAHS group(25 cases). 30 cases who underwent PSG and were excluded from OSAHS were selected as obesity group,and 30 people with normal BMI were selected as control group. The BMI,AHI,LSaO2 and MSaO2 of all the groups were detected,and the levels of plasma hyaluronic acid,procollagen Ⅲ,collagen Ⅳ and laminin were also detected one day after PSG examination. Results The levels of plasma hyaluronic acid,procollagen Ⅲ,collagen Ⅳ and laminin in the four groups showed statistically significant difference(P < 0. 05). Compared with the control group,the above mentioned indicators in obesity group,normal BMI + OSAHS group and obesity + OSAHS group were all higher(P < 0. 05);compared with the obesi-ty group,the above mentioned indicators in normal BMI + OSAHS group and obesity + OSAHS group were also higher( P <0. 05);compared with normal BMI + OSAHS group,the above mentioned indicators were in obesity + OSAHS group were higher (P < 0. 05). The levels of plasma hyaluronic acid,procollagen Ⅲ,collagen Ⅳ and laminin were positively correlated with AHI and BMI(P < 0. 05),but were negatively correlated with LSaO2 and MSaO2(P < 0. 05). Conclusion The levels of plasma hyaluronic acid,procollagen Ⅲ,collagen Ⅳ and laminin were positively correlated with AHI and BMI and OSAHS could lead to hepatic fibrosis.关键词
睡眠呼吸暂停,阻塞性/肝硬化/透明质酸/前胶原/胶原Ⅳ型/层黏连蛋白Key words
Sleep apnea,obstructive/Liver cirrhosis/Hyaluronic acid/Procollagen/Collagen type Ⅳ/Laminin分类
医药卫生
