中国全科医学Issue(35)：4245-4247,3.DOI:10.3969/j.issn.1007-9572.2014.35.025
降钙素原水平对老年慢性阻塞性肺疾病急性加重期选用抗菌药物的指导价值
Guidance Values of Procalcitonin in Choosing Antimicrobial Drugs in Acute Exacerbation of Elderly COPD
摘要
Abstract
Objective To investigate the guidance values of procalcitonin( PCT)in choosing antimicrobial drugs in a-cute exacerbation of elderly COPD. Methods From January 2012 to February 2014,in Liandu People Hospital,250 acute COPD patients had PCT after admission were divided into groups A(n=48,given PCT<0. 10μg/L without antibacterials at ad-mission),B(n=72,PCT<0. 1 μg/L within 6 h of onset or 0. 10-0. 25 μg/L at admission,PCT determined Alt. dieb;u-sing antibacterials if PCT>0. 25 μg/L Alt. dieb until normal PCT or adjusting antibiotic therapy),C( n=130,PCT>0. 25μg/L,using antibacterials if PCT>0. 25 μg/L Alt. dieb until normal PCT or adjusting antibiotic therapy). The indicators and results of laboratory examinations and prognosis were analyzed comparatively. Results There was significant difference in medi-cal history,clinical symptom,illness degree and indicators of laboratory examination between 3 groups( P<0. 05 ). Group A were not given antibacterials;in group B PCT detected Alt. dieb,40 patients with PCT>0. 25 μg/L improved after antibiotic therapy(55. 6%),32 with PCT<0. 25 μg/L were not given antibiotic therapy(45. 7%);in group C,antibiotic therapy were given,30 changed antibiotic therapy due cough,sputum,dyspnea with improvement,122 had good prognosis,6 transferred to high-level hospitals,2 died in days 5,6 after admission. Conclusion The acute COPD patients with high PCT level have in-flammatory response and are in serious condition. Primary hospitals can judge the existence of inflammatory response and disease severity according to PCT levels and take PCT as a reference tool for choosing,changing or evaluating the effects of antibacterial drugs.关键词
降钙素原/肺疾病,慢性阻塞性/抗菌药Key words
Procalcitonin/Pulmonary disease,chronic obstructive/Anti-bacterial agents分类
医药卫生引用本文复制引用
雷振东,邱泽亮,雷李美,黄丽央,陈铃,应项尖,陈雪峰..降钙素原水平对老年慢性阻塞性肺疾病急性加重期选用抗菌药物的指导价值[J].中国全科医学,2014,(35):4245-4247,3.基金项目
浙江省丽水市科技局2012年公益性技术应用项目（2012JYZB10）---降钙素原指导基层医院社区呼吸道感染患者抗菌药物合理应用的研究 （）
