中国全科医学Issue(2)：172-175,4.DOI:10.3969/j.issn.1007-9572.2015.02.012
卡介菌多糖核酸对慢性阻塞性肺疾病T淋巴细胞核仁区酸性非组蛋白水平的影响
Effects of BCG - polysaccharide Nucleic Acid on T - lymphocytes Argyrophilic Nucleolar Organizer Proteins in COPD Patients
摘要
Abstract
Objective To detect the effects of BCG - polysaccharide nucleic acid on peripheral blood T - lymphocytes argyrophilic nucleolar organizer proteins ( Ag - NORs) in patients with chronic obstructive pulmonary disease ( COPD). Methods Fifty patients of acute exacerbation of COPD( AECOPD) were divided randomly into groups AECOPD study, AECOPD control and 40 remitting COPD(RCOPD)patients into groups RCOPD study,RCOPD control in Peopleˊs Hospital of Guizhou from january 2012 to june 2013. Four groups were given conventional treatment,the study groups given additional BCG- polysaccharide nucleic acid,the courses lasted 1 month. Taking nucleolar silver staining/ nuclear silver staining(I/ S% )as the test index of Ag - NORs,a staining analysis on peripheral blood T - lymphocyte Ag - NORs was performed before and after treatment. Results There was no significant difference in Ag - NORs level between groups AECOPD study,control before treatment(P > 0. 05),higher in AECOPD study group than in AECOPD control after treatment(t = - 1. 708,P < 0. 05). No difference was noted in Ag - NORs between groups RCOPD study,control before treatment(P > 0. 05),and higher in RCOPD study group than in RCOPD control group after treatment(t = - 1. 647,P < 0. 05). One patient from AECOPD study group and 1 from RCOPD study group had local swelling on injection sites and regressed spontaneously. No obvious adverse reactions appeared in the other patients. Conclusion BCG - polysaccharide nucleic acid can increase T - lymphocyte Ag - NORs level and improve its immune function in COPD patients.关键词
肺疾病,慢性阻塞性/卡介菌多糖核酸/核仁区酸性非组蛋白/T 淋巴细胞/免疫Key words
Pulmonary disease,chronic obstructive/BCG - polysaccharide nucleic acid/Argyrophilic nucleolar organizer proteins/T - lymphocytes/Immunity分类
医药卫生引用本文复制引用
唐孝庆,张程,叶贤伟,刘维佳,张湘燕..卡介菌多糖核酸对慢性阻塞性肺疾病T淋巴细胞核仁区酸性非组蛋白水平的影响[J].中国全科医学,2015,(2):172-175,4.基金项目
贵州省发展和改革委员会资助项目 （）
