摘要
Abstract
Objective To investigate the differences of heart rate variability(HRV)between different sleeping stages in healthy subjects. Methods The test data were taken from Sleep Heart Rate and Stroke Volume Data Bank including the sleep sinus rhythm RR interval(RRI)sequence and sleep phase data of 45 healthy subjects. RRI sequence was extracted from the ECG data whose sampling rate was 500 Hz. Sleep phase data were divided into 3 time phases:WAKE,rapid eye movement (REM),non - rapid eye movement( NREM). The sleep RRI sequence was separated into time slices(5 min as a unit). HRV indictors of each unit were calculated. The indicators of frequency domain method( FDM) included very low frequency (VLF),low frequency(LF),high frequency(HF),total energy(TP)and LF and HF ratio(LF/ HF). The time domain method(TDM)indicators included 5 min mean HR,standard deviation of all normal - to - normal intervals( SDNN),root mean square of successive differences(RMSSD),percentage of differences exceeding 50 ms between adjacent normal number of intervals(pNN50)and R - R interval variation(RRIV). The sleep time phase number contained in time slices were recorded.Results A total of 3 952 units of time slices,1 477 eligible were enrolled including 240(16. 2% )in WAKE,233(15. 8% ) in REM,1 004(68. 0% ) in NREM. There was significant difference in HRV indicators between varying sleep time phase FDMs(P < 0. 05),there into NREM was different from WAKE in VLF,LF,TP,LF/ HF(P < 0. 05);NREM different from REM in VLF,LF,HF,TP,LF/ HF(P < 0. 05),REM different from WAKE in HF(P < 0. 05). There was difference in HRV indicators between varying sleep time phase TDMs( P < 0. 05),there into NREM was different from WAKE in HR, SDNN,RRIV(P < 0. 05),NREM from REM in HR,SDNN,RRIV,RMSSD,pNN50(P < 0. 05),REM from WAKE in RMSSD,pNN50(P < 0. 05). By Spearman rank correlation analysis,RMSSD,pNN50 were positively correlated with HF(rs= 0. 95,0. 94,P < 0. 001),RRIV positively with LF(rs = 0. 79,P < 0. 001),SDNN positively with TP(rs = 0. 98,P <0. 001),RMSSD positively with pNN50(rs = 0. 98,P < 0. 001). Conclusion The excitability of parasympathetic nerve is high in NREM,and that of sympathetic nerve in REM prevails. Both TDM and FDM can reflect the HRV difference between different sleep time phases.关键词
心率变异性/睡眠时相/快速眼动期/健康人Key words
Heart rate variability/Sleeping stages/Rapid eye movement stage/Healthy分类
医药卫生
