中国全科医学Issue(2)：211-214,4.DOI:10.3969/j.issn.1007-9572.2015.02.022
脐血干细胞联合人参促分化合剂治疗失代偿期肝硬化疗效研究
umbilical Cord Blood Stem Cell Transplantation and Ginseng Promoting Differentiation Mixture in Patients with Decompensated Cirrhosis
摘要
Abstract
Objective To study the effect of umbilical cord blood stem cell transplantation( UCBCT) and ginseng promoting differentiation mixture(GPDM)therapy on decompensated cirrhosis(DC). Methods From February 2012 to April 2013,in Department of Gastroenterology,Harrison International Peace Hospital,30 DC patients underwent conventional liver protection therapy. Cell isolation technics was used to draw UCBC from umbilical cord blood( UCB) and implanted UCBC suspension into the liver through arteria hepatica propria. After successful implantation,patients were given GPDM adjuvant therapy,14 d. We observed liver function indicators including ALT, AST, albumin ( Alb ), total bilirubin ( TBiL), prothrombin activity( PTA) in weeks 16 after treatment,serum fibrosis markers including hyaluronic acid( HA),laminin (LN),procollagen Ⅲ(PC - Ⅲ),Ⅳ collagen(Ⅳ - C)in weeks 24 after treatment. In weeks 24 after treatment,patients underwent CT examination,the changes of liver imaging were observed including CT values of liver maximum cross - sectional area and liver plain scan. Results Plasma ALT,AST,TBiL were lower,Alb,PTA higher in weeks 16 after treatment than before treatment(P < 0. 05),and HA,PC - Ⅲ,Ⅳ - C,LN lower,liver maximum cross - sectional area larger in weeks 24 after treatment than before treatment(P < 0. 05). There was no significant difference in liver plain scan value between before and after treatment(P > 0. 05). Conclusion UCBCT combined with GPDM,which can improve the liver function and repair liver damages in DC patients,is a effective clinical treatment of DC.关键词
胎血/脐血干细胞移植/肝硬化/人参促分化合剂Key words
Fetal blood/Cord blood stem cell transplantation/Liver cirrhosis/Ginseng promote differentiation mixture分类
医药卫生引用本文复制引用
陈玉梅,王丽华,李炳茂,孙建顺,张丽贤,杨彬..脐血干细胞联合人参促分化合剂治疗失代偿期肝硬化疗效研究[J].中国全科医学,2015,(2):211-214,4.基金项目
河北省中医药管理局科研基金项目 （）
