中国全科医学Issue(3)：263-268,6.DOI:10.3969/j.issn.1007-9572.2015.03.007
新疆地区汉族人群转录因子7类似物2基因多态性与2型糖尿病的相关性研究
Relationship between Transcription Factor 7 - like 2 Gene and Type 2 Diabetes Mellitus among Han Population in Xinjiang
摘要
Abstract
Objective To investigate the relationship between polymorphisms of transcription factor 7 - like - 2 (TCF7L2) gene ( rs11196218,rs10749127,rs290487,rs290481 ) and type 2 diabetes mellitus ( T2DM ) among Han population in Xinjiang. Methods 164 Han patients with T2DM who were treated in the First Affiliated Hospital of Xinjiang Medical University from November 2013 to February 2014,were included in T2DM group,at the same time,195 healthy people who received physical examination were included in control group. The height,body mass,abdominal circumference,blood pressure,levels of blood glucose,glycated hemoglobin( HbA1c ),insulin,C - peptide,blood lipids and uric acid were measured and recorded. Peripheral blood DNA was extracted,genotype and allele frequency were detected for TCF7L2 gene rs11196218,rs10749127, rs290487, rs290481. The influence factors for T2DM were analysed by multivariable Logistic regression. Results There was no significant difference in systolic blood pressure(SBP)between control group and T2DM group (P ﹥ 0. 05). The diastolic blood pressure(DBP),levels of three acyl glycerin(TG),total cholesterol(TC),low - density lipoprotein cholesterol(LDL - C),fasting blood glucose and HbA1c of patients in T2DM group were significantly higher than those of patients in control group,but the high density lipoprotein cholesterol(HDL - C)level of patients in T2DM group was significantly lower than that of patients in control group(P ﹤ 0. 05). There was no significant difference in genotype and allele frequency distribution of rs11196218 and rs290481 between the control group and T2DM group( P ﹥ 0. 05 ) . There was significant difference in distribution of rs10749127 TT genotype between control group and T2DM group(P ﹤ 0. 05). There were significant differences in genotype and allele frequency distribution of rs290487 CC between control group and T2DM group(P ﹤0. 05). There were significant differences in levels of fasting glucose and uric acid among T2DM patients with different rs10749127 genotypes(CC,CT and TT)(P ﹤ 0. 05). But there was no significant difference in various indexes among CC, CT and TT genotype of rs290487( P ﹥ 0. 05). According to multivariable Logistic regression analysis results,rs290487 CC genotype,abdominal circumference,BMI,levels of fasting blood glucose and HbA1c had correlation with T2DM(P ﹤ 0. 05). Conclusion TCF7L2 gene rs10749127 and rs290487 are correlated with the onset of T2DM among Han population in Xinjiang, but the correlation between rs11196218,rs290481 and T2DM are not found.关键词
糖尿病,2 型/转录因子 7 类似物 2/基因/多态性,单核苷酸Key words
Diabetes mellitus,type 2/Transcription factor 7 - like 2/Genes/Polymorphism,single nucleotide分类
医药卫生引用本文复制引用
曹冰,朱筠,张明琛..新疆地区汉族人群转录因子7类似物2基因多态性与2型糖尿病的相关性研究[J].中国全科医学,2015,(3):263-268,6.基金项目
新疆维吾尔自治区自然科学基金资助项目 （）
