朱帝文 1张海潇 1顾俊鹏 1纪卫政 1曹耿飞 1任伟新1
作者信息
- 1. 830054 新疆乌鲁木齐市，新疆医科大学第一附属医院介入放射科
- 折叠
摘要
Abstract
Objective To analyse the angiographic appearance of patients with primary hepatocellular carcinoma who are treated with arterial infusion with Bevacizumab combined with transcatheter arterial chemoembolization( TACE),and to evaluate the efficacy and safety of the treatment. Methods 13 patients with primary hepatocellular carcinoma who underwent TACE at least 1 time in the First Affiliated Hospital of Xinjiang Medical University from October 2012 to August 2013,were selected as study subjects,ART score of each case was ≥ 2. 5 points after treatment,all cases were treated with arterial infusion with Bevacizumab combined with TACE. After combination treatment,all cases were followed up from November 2012 to March 2014,all cases received reexamination every 4 - 8 weeks,the therapeutic effects and adverse reactions were evaluated,and the angiographic appearance was observed. Results After the first treatment with arterial infusion with Bevacizumab combined with TACE,3 patients did not undergo the second combination treatment because of progression disease(PD),the other 10 patients received the second combination treatment. The angiographic appearance showed the number of tumor vascular decreased significantly,the remaining vessels appeared normal,and some lesions without iodine oil particles deposition were not visualized in the delayed phase;the diameter of normal hepatic artery decreased,and blood flow volume of tumor tissues decreased. During follow - up,1 patient lost contact with research team due to ways of contact changed. Among the remaining 12 patients,4 patients died,8 patients survived. The mean progression free survival was 356. 5 d(220 - 452 d),the median overall survival time was 410. 0 d(246 - 585 d). According to results of postoperative efficacy evaluation,nobody experienced a complete response(CR),a partial response(PR)was observed in two patients,and eight showed a stable disease( SD),the other three cases showed a PD. The drug - related and treatment - related adverse effects were not observed. Conclusion When treating hepatocellular carcinoma patients with arterial infusion with Bevacizumab combined with TACE,the decreased number of tumor vascular and tumor vascular normalization can be seen through arteriography,the combination treatment is safe and effective,and is a valid alternative strategy for the patients whose ART score are ≥ 2. 5 points after TACE treatment.关键词
肝肿瘤/血管生成抑制剂/化学栓塞,治疗性/血管造影术Key words
Liver neoplasms/Angiogenesis inhibitors/Chemoembolization,therapeutic/Angiography分类
医药卫生
