中国全科医学Issue(8)：919-923,5.DOI:10.3969/J.iSSn.1007-9572.2015.08.015
淋巴细胞亚群预测脓毒症患者死亡风险的主成分分析
Lymphocyte Subsets to Predict the Principal Component of Risk of Death in Sepsis Patients
潘东峰 1李富荣 1梁诗颂 1祁科乐 1季新忠 1柯进芳1
作者信息
- 1. 750021宁夏回族自治区银川市，宁夏人民医院急诊科，检验科
- 折叠
摘要
Abstract
Objective To observe the predictive value of lymphocyte subsets for mortality risk in sepsis patients. Methods From March 2012 to December 2013 ,101 sepsis patients were enrolled in this study and divided in EICU and ICU of the Ningxia Peopleˊs Hospital, according to prognosis, into groups survival ( n = 80 ), death ( n = 21 ). The level of lymphocyte subsets were detected at 48 hours after admission,and comprehensive predictor was extracted by principal component analysis. The predictive values of lymphocyte subsets for mortality risk of sepsis patients were evaluated. Results There was significant difference in total T lymphocytes,total B lymphocytes,helper/regulatory T lymphocytes( Th),suppressor/cytotoxic T lymphocytes(Ts),Th/Ts,total NK cells between different types of sepsis patients(P<0. 05). In severe sepsis patients, suppressor/cytotoxic T lymphocytes were lower in death group than in survival group ( P <0. 05 );in septic shock patients, auxiliary/regulatory T lymphocytes were lower in death group than in survival group(P<0. 05). The area under the receiver-operating curve of lymphocyte subsets comprehensive predictor predicting sepsis patientsˊ death risks was 0. 983〔95% CI (0. 934,0. 998)〕. Conclusion Lymphocyte subsets express abnormally in sepsis patients. The comprehensive predictor of lymphocyte subsets is of high predictive values in predicting sepsis patientsˊdeath risks.关键词
脓毒症/淋巴细胞亚群/预后/主成分分析Key words
sepsis/Lymphocyte subsets/Prognosis/Principal component analysis分类
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潘东峰,李富荣,梁诗颂,祁科乐,季新忠,柯进芳..淋巴细胞亚群预测脓毒症患者死亡风险的主成分分析[J].中国全科医学,2015,(8):919-923,5.
