中国全科医学Issue(8)：969-971,3.DOI:10.3969/J.iSSn.1007-9572.2015.08.028
外周血Th17和CD4+ CD2+5调节性T细胞变化与患儿支气管哮喘活动状态的相关性研究
Correlation between State of Bronchial Asthma Children and Peripheral Blood Th17 and CD4+ CD2+5 Regulatory T Cells Changes
摘要
Abstract
Objective To investigate the correlation of the active state of asthma with the peripheral blood Th17 and CD4+ CD2+5 regulatory T cells(Treg)change on children. Methods From January 2010 to December 2013,98 cases of children with asthma in shaoxing Peopleˊs Hospital specialist outpatient clinic were selected for chronic duration group,meanwhile 40 cases of remission asthma children in the same hospital were selected as remission group. 40 cases of healthy children in child health clinic were selected as healthy control group. Using flow cytometry to measure childrenˊs peripheral blood Th17 and CD4+CD2+5 Treg. Results In three groups comparison,there were significant differences among Th17,CD4+CD2+5 Treg and Th17/CD4+CD2+5Treg(F =5. 274,7. 813,3. 526,P <0. 05). There was positive relationship between the score of Th17 cells, Th17/CD4+CD2+5Treg and C-ACT(r=0. 823,0. 485,P<0. 05). CD4+CD2+5Treg was negatively related with C-ACT(r= -0. 562,P<0. 05). Th17 cells was negatively related with CD4+CD2+5Treg(r= -0. 273,P<0. 05). Conclusion Children with chronic asthma duration,Th17 immune response enhanced,and CD4+ CD2+5 Treg immune function declined,the severity of asthma and peripheral blood Th17 /Treg of the immune imbalances are closely related.关键词
哮喘/T淋巴细胞,辅助诱导/T淋巴细胞,调节性/儿童Key words
Asthma/T-lymphocytes,helper-inducer/T-lymphocytes,regulatory/Child分类
医药卫生引用本文复制引用
陈啸洪,李华浚,姚欢银,朱芹,张佩红,章杭湖,刘小群,周国中..外周血Th17和CD4+ CD2+5调节性T细胞变化与患儿支气管哮喘活动状态的相关性研究[J].中国全科医学,2015,(8):969-971,3.基金项目
绍兴市科技计划项目 （）
