中国全科医学Issue(10)：1219-1221,3.DOI:10.3969/j.issn.1007-9572.2015.10.029
扶正化瘀胶囊联合阿德福韦酯治疗慢性乙型肝炎的临床疗效和机制研究
Clinical Effect and Corresponding Mechanism of Fuzheng Huayu Capsule Combined With Adefovir Dipivoxil in the ;Treatment of Chronic Hepatitis B
摘要
Abstract
Objective To evaluate the clinical effect of Fuzheng Huayu capsule combined with adefovir dipivoxil on patients with chronic hepatitis B ( CHB ), and to investigate the corresponding mechanism of the regimen. Methods We recruited patients with CHB who were admitted into Huzhou Central Hospital from April,2011 to February,2013 and accorded with inclusion and exclusion criteria of the study. The patients were randomly assigned into control group(n=67)and trial group (n=67). The control group received treatment with adefovir dipivoxil and the trial group received treatment with both Fuzheng Huayu capsule and adefovir dipivoxil;treatment of both groups lasted for one year continuously. Clinical indicators of the two groups were compared. Results Before treatment, the two groups were not significantly different in CD40 , CD11C , CD86 , HBV-DNA,DNA-,IFN-γand DCs stimulated activity(P ﹥0. 05). After treatment,the two groups were significantly different in CD40,CD11C,CD86,HBV-DNA,DNA -,IFN-γ and DCs stimulated activity(P ﹤0. 05). After treatment, the two groups were significantly different in CD40,CD11C,CD86,HBV-DNA,DNA - and IFN-γ(P ﹤0. 05)and not significantly different in DCs stimulated activity ( P ﹥0. 05 ) . Conclusion Fuzheng Huayu capsule combined with adefovir dipivoxil can effectively improve DCs function and has better clinical effect.关键词
乙型肝炎/扶正化瘀胶囊/阿德福韦酯/树突细胞Key words
Hepatitis B/Fuzheng Huayu capsule/Adefovir dipivoxil/Dendritic cells分类
医药卫生引用本文复制引用
刘春燕,张龙琪..扶正化瘀胶囊联合阿德福韦酯治疗慢性乙型肝炎的临床疗效和机制研究[J].中国全科医学,2015,(10):1219-1221,3.基金项目
浙江省医药卫生科技计划 （）
