Abstract
Objective To analysis the pathogenic bacteria of continuous ambulatory peritoneal dialysis - related peritonitis(CAPDrp)and their drug resistance and independent risk factors. Methods From May 1,2009 to May 1,2014, in Weifang People's Hospital,167 Han patients who had continuous ambulatory peritoneal dialysis( CAPD)were divided into groups non - infected(n = 80),infected(n = 87). Patients' general data,laboratory parameters were collected,and bacterial,fungal cultures and drug sensitive test were carried out. ResuIts CAPDrps occurred 109 case -times in infected group,79 case-time(72. 5%)pathogenic bacteria cultures were positive. A total of 93 strains of pathogenic bacteria were isolated and identified,including 48 strains(51. 6%)of G+ cocci,mainly Staphylococcus Epidermidis(21. 5%),and 39 strains(41. 9%)of G- bacilli,mainly Escherichia coli(30. 1%),and 6 strains(6. 5%)of fungus. G+ cocci were sensitive to vancocin and their drug resistance to penicillin was the highest( 81. 0%). G- bacilli were well sensitive to amikacin and imipenem and their drug resistance higher to levofloxacin, cefotaxime, gentamicin, ceftriacone. Fungi were sensitive to fluconazole,5-fluorocytosine,amphoterincin. There was significant difference in age,hypertension,coronary heart disease (CHD),diabetes,total protein,albumin between 2 groups(P ﹤0. 05). CHD〔β =1. 166,Wald χ2 =10. 085,OR =3. 210,95%CI(2. 491,3. 929),P=0. 001〕and diabetes〔β=1. 502,Waldχ2 =16. 833,OR=4. 489,95%CI(3. 771, 5. 206),P﹤0. 001〕were independent risk factors of CAPDrp. In this study,infection rate of CAPDrp was 55. 07 month /times. ConcIusion CAPDrp pathogenic bacteria are mainly Staphylococcus Epidermidis,Escherichia coli,and G+ bacterial are sensitive to vancocin and G- bacterium sensitive to amikacin and imipenem. CHD,diabetes are independent risk factors of CAPDrp.关键词
腹膜炎/腹膜透析,持续不卧床/致病菌/耐药性/危险因素Key words
Peritonitis/Peritoneal dialysis,continuous ambulatory/Pathogens/Antibacterials/Risk factors分类
医药卫生
