中国全科医学Issue(12)：1390-1395,6.DOI:10.3969/j.issn.1007-9572.2015.12.009
经皮穴位电刺激对老年患者腹腔镜直肠癌切除术后认知功能的影响研究
Effect of Transcutaneous Acupoint Electrical Stimulation on Postoperative Cognitive Function in Elderly Patients Undergoing Laparoscopic Resection of Rectal Cancer
摘要
Abstract
Objective To observe the effect of transcutaneous acupoint electrical stimulation(TAES)on postoperative cognitive function in elderly patients undergoing laparoscopic resection of rectal cancer and its possible mechanism. Methods Sixty elderly patients with rectal cancer who underwent laparoscopic Dixon surgery in Department of Surgical Oncology in the First Hospital Affiliated to Wenzhou Medical University from June 2011 to May 2014,were randomly divided into TAES group(group E,30 cases)and control group( group C,30 cases)by random number table method. Total intravenous anesthesia were selected for patients of two groups,group E were continually treated with TASE from 30 minutes before anesthesia to the end of operation. The mini - mental state examination( MMSE)was used to evaluate the changes of cognitive function during the perioperative period,serum levels of superoxide dismutase( SOD),malondialdehyde( MDA)and S100β were detected at different time points. Results There was no significant interaction between treatment method and time(P > 0. 05);there were significant differences in MMSE scores among groups( P < 0. 05);there were significant differences in MMSE scores among different time points(P < 0. 05);MMSE scores 1,3,5 days after operation in group E were significantly higher than those in group C respectively(P < 0. 05). The severity degree of POCD 1,3 days after operation of patients in group E were significantly lower than those in group C respectively(P < 0. 05). There was no significant difference in severity degree of POCD 5,7 days after operation between two groups(P > 0. 05). There was no significant interaction between treatment method and time(P >0. 05);there were significant differences in serum levels of SOD,MDA and S100β among groups( P < 0. 05);there were significant differences in serum levels of SOD,MDA and S100β among different time points(P < 0. 05). The levels of SOD in group E were higher than those in group C at the end of operation,and 2,6,24 h after operation respectively(P < 0. 05). The levels of MDA and S100β in group E were significantly lower than those in group C 2,6,24 h after opteration respectively (P < 0. 05). Conclusion Laparoscopic resection of rectal cancer in elderly patients can cause POCD,TAES has a protective effect on cerebral function by increasing SOD level,inhibiting the aggregation of MDA and reducing the release amount of S100β, thus can significantly reduce the incidence of POCD among patients.关键词
结直肠肿瘤/认知障碍/腹腔镜检查/电刺激疗法Key words
Colorectal neoplasms/Cognition disorders/Laparoscopy/Electric stimulation therapy分类
医药卫生引用本文复制引用
倪剑武,蒋柳明,周一敏,莫云长,吴群,王均炉..经皮穴位电刺激对老年患者腹腔镜直肠癌切除术后认知功能的影响研究[J].中国全科医学,2015,(12):1390-1395,6.基金项目
国家自然科学基金资助项目（81273926）；国家重点基础研究发展计划973计划 （）
