中国全科医学Issue(13)：1587-1590,4.DOI:10.3969/j.issn.1007-9572.2015.13.027
耐甲氧西林金黄色葡萄球菌和耐甲氧西林凝固酶阴性球菌检出率与常用抗球菌药物使用强度的相关性分析
Correlation Analysis Between the Detection Rate of MRSA and MRCNS and the Use Intensity of Common Antibacterial Drugs
摘要
Abstract
Objective To investigate the correlation between the detection rate of MRSA and MRCNS and the use intensity of common antibacterial drugs in order to provide references for rational selection and use of antibacterial drugs and reduce the generation of special drug-resistance bacteria. Methods We collected relevant data from the bacteriology lab and the information section of Children's Hospital of Kaifeng from 2009 to 2013. The yearly detection rate of MRSA and MRCNS and the use intensity of common antibacterial drugs were calculated,and Pearson correlation analysis was conducted to examine the correlation between them. Results The detection rate of MRSA had a strong positive correlation with the use intensity of fusidic acid(r=0. 951,P=0. 013)and azithromycin(r=0. 896,P=0. 04)and had no correlation with cefuroxime(r= -0. 837, P﹥0. 05)and cefotiam(r=0. 561,P ﹥0. 05). The detection rate of MRCNS had a strong positive correlation with the use intensity of fusidic acid(r =0.980,P =0.03)and azithromycin(r =0.940,P =0.017)and had no correlation with cefuroxime(r= -0. 692,P﹥0. 05)and cefotiam(r=0. 156,P﹥0. 05). Conclusion Azithromycin and fusidic acid are not inappropriate for routine use,for they are likely to induce drug resistance. The strict control on the use of clinic antibacterial drugs is of significance to delay or prevent bacterial drug resistance.关键词
耐甲氧西林金黄色葡萄球菌/耐甲氧西林凝固酶阴性球菌/检出率/抗菌药物使用强度/相关分析Key words
Methicillin-resistant staphylococcus aureus/Methicillin-resistant coagulase negative staphylococcus/Detection rate/Use intensity of antibacterial drugs/Correlation analysis分类
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董懿珍,张伟,张博..耐甲氧西林金黄色葡萄球菌和耐甲氧西林凝固酶阴性球菌检出率与常用抗球菌药物使用强度的相关性分析[J].中国全科医学,2015,(13):1587-1590,4.基金项目
常州四药临床药学科研基金 （）
