中国全科医学Issue(17)：1995-2000,6.DOI:10.3969/j.issn.1007-9572.2015.17.003
代谢综合征及其组分与老年血尿酸水平的关系
Correlation Between Serum Uric Acid Levels in the Elderly and Metabolic Syndrome and Its Components
摘要
Abstract
Objective To investigate the correlation between serum uric acid ( SUA ) levels in the elderly and metabolic syndrome( MS ) and its components. Methods By using random cluster sampling method, we enrolled 5 010 permanent residents aged from 60 to 70 in Renqiu. Face-to-face questionnaire survey about health,physical examination and laboratory inspection were conducted on the subjects. According to the diagnostic criteria of MS in the Guidelines on Prevention and Treatment of Blood Lipid Abnormality in Chinese Adults,the subjects with MS were found out and grouped by the quartile of SUA level. Then the correlation between MS and SUA was investigated. Results With the increase of SUA,the proportion of male subjects increased,the proportion of female subjects decreased,the incidence of MS,stroke and TIA increased,the rate of smoking,excessive alcohol consumption and a lack of physical exercise increased,the usage ratio of antiplatelet drugs increased,the rate of passive smoking decreased,waistline,BMI,systolic pressure,diastolic pressure,FPG,TG and HOMA-IR increased,and the level of TC and HDL-C decreased,with all the differences significant(P<0. 05). The MS morbidity rates of male subjects in the four quartiles serum uric acid were 15. 77%,19. 59%,23. 98% and 37. 89% respectively,and that of the women subjects were 29. 83%,32. 58%,41. 63% and 59. 47% respectively. As the serum uric acid level increased, the morbidity rates of both male and female subjects increased. After adjusting for gender,age and other components of MS,the Logistic regression analyses showed that SUA level was the independent risk factor ( P<0. 01 ) for central obesity and high TG level in male subjects and the independent risk factor(P <0. 01)for central obesity,hypertension,high TG level and low LDL-C level in female subjects. Compared with the first quartile,the third and fourth quartiles were associated with higher( P<0. 01) risk in MS. The higher the quartile was,the higher the SUA level was for both male subjects and female subjects,so was the HUA morbidity rate ( P <0. 01 ). Conclusion SUA level is closely associated with MS components, and is an important element of MS. We suggest SUA level be taken as an indicator in MS predication and early precaution.关键词
代谢综合征X/尿酸/高尿酸血症/老年人Key words
Metabolic syndrome X/Uric acid/Hyperuricemia/Aged分类
医药卫生引用本文复制引用
高素颖,杨红娜,颜应琳,于凯,王拥军,赵永娜,李芳,张广波,刘东亮,何艳..代谢综合征及其组分与老年血尿酸水平的关系[J].中国全科医学,2015,(17):1995-2000,6.基金项目
河北省科技支撑计划项目 （）
