中国全科医学Issue(17)：2105-2106,2110,3.DOI:10.3969/j.issn.1007-9572.2015.17.029
Semaphorin3 A抗骨质疏松作用靶点的研究进展
Research Progress of the Action Target of Semaphorin3A on Anti -osteoporosis
摘要
Abstract
Bone remodeling is a dynamic and continuous process which consists of two phases:the absorption and removal of bone by osteoclasts and the formation of new bone by osteoblasts and the imbalance of this can cause severe skeletal disorders. The aiti -osteoporosis drugs used commonly in clinic nowadays have a general problem:it inhibits not only bone absorption,but also bone formation as well. Recent studies have shown that Semaphorin3A,a secreted protein produced by osteoblasts,can inhabit bone absorption and at the same time promote bone formation,and therefore produce a new class of dual-action therapeutic agent for osteoporosis and a new perspective of treatment against osteoporosis. This article briefly reviews the research progress of molecular mechanism of Semaphorin3A targeting on anti-osteoporosis.关键词
信号素3A/骨质疏松/骨重塑/破骨细胞/成骨细胞Key words
Semaphorin-3A/Osteoporosis/Bone remodeling/Osteoclasts/Osteoblasts分类
医药卫生引用本文复制引用
郭蓓,李法琦..Semaphorin3 A抗骨质疏松作用靶点的研究进展[J].中国全科医学,2015,(17):2105-2106,2110,3.基金项目
国家临床重点专科建设项目 （）
