中国人兽共患病学报Issue(7)：761-765,5.DOI:10.3969/cjz.j.issn.1002-2694.2014.07.020
结核分枝杆菌Pup-蛋白酶体系统研究进展
Study progress of prokaryotic ubiquitin-like protein (Pup)-proteasome system of My cobacterium tuberculosis
摘要
Abstract
Proteasome pathway is another major pathway of protein degradation in addition to lysosome in eukaryotic cell ,which involved a number of physiological functions regulation in cell .Prokaryotic ubiquitin-like protein was found in My-cobacterium tuberculosis in 2008 .With the effect of co-factor Dop ,PafA and Mpa ,Pup can mark a variety of protein ubiquitina-tion followed by importing them into proteasomal degradation .The target protein of Pup-proteasome system like FabD ,PanB , Ino1 ,Icl ,SodA ,and MtrA are involved with metabolism ,signal transduction pathways ,virulence factors ,pathogenicity and the persistence of bacteria in the host cell .Proteasome inhibitor make the function of proteasome restricted and the accumula-tion of Pup’s labeled substrate result in changes in the expression of gene indirectly ,which impacted the ability of resistance to outside pressure and the pathogenicity of Mycobacterium tuberculosis . The finding Pup-proteasome system reveals a novel mechanism of protein degradation in prokaryotes ,which is expected to become a new target of treatment of anti-TB drugs . Here ,we summarize the progress on the Pup-proteasome system in Mycobacterium tuberculosis .关键词
结核分枝杆菌/Pup-蛋白酶体/致病性/蛋白酶体抑制剂Key words
Mycobacterium tuberculosis/prokaryotic ubiquitin-like protein(Pup)-proteasome/pathogenicity/protea-some inhibitors分类
医药卫生引用本文复制引用
朱彬,张万江..结核分枝杆菌Pup-蛋白酶体系统研究进展[J].中国人兽共患病学报,2014,(7):761-765,5.基金项目
国家自然科学基金项目（No ．81260261，81160192）；新疆生产建设兵团医药专项资金项目 （）
