中国人兽共患病学报Issue(12)：1201-1205,5.DOI:10.3969/cjz.j.issn.1002-2694.2014.12.006
探讨小鼠肌肉组织中老化淀粉样变纤维的传播性
Transmission of mouse senile amyloid fibrils in skeletal muscle
摘要
Abstract
ABSTRACT:Recently ,prion‐like transmission has been found in various amyloidosis .AApoAII amyloid fibrils in mouse senile amyloidosis have exhibited transmissibility .AApoAII amyloid fibrils ,which were excreted from mice and contained in fe‐ces or milk ,cause mouse senile amyloidosis .However ,transmissibility of AApoAII amyloid fibrils through other pathways has not yet been established .In this study ,we injected AApoAII amyloid fibrils into R1 .P1‐A poa2c mice to induce AApoAII sys‐temic amyloidosis .Two months later ,AApoAII amyloid fibrils ,which deposited in the skeletal muscles of amyloid‐affected mice ,were used to induce AApoAII systemic amyloidosis .Mouse senile amyloidosis which deposited in skeletal muscles could induce secondary transmission of AApoAII amyloidosis .The evidence of transmission through skeletal muscles in non‐prion systemic amyloidosis is found in our study .This pathway of transmission provides new insight into the potential for food‐borne pathogenesis and etiology of systemic amyloidosis .关键词
淀粉样变纤维/骨骼肌/传播Key words
mouse senile amyloid fibrils/skeletal muscle/secondary transmission分类
医药卫生引用本文复制引用
霍佳,钱俊乔,李陈莉,樋口京一,郭浅妤,钱金泽..探讨小鼠肌肉组织中老化淀粉样变纤维的传播性[J].中国人兽共患病学报,2014,(12):1201-1205,5.基金项目
第51批国家博士后基金面上资助二等资助项目（ No ．2012M510943），河北省青年自然科学基金项目（No ．H2012206080），国家自然科学基金青年基金项目（No ．81300606），2012年河北省留学人员科技活动项目择优资助经费启动类项目（No ．2012），2014年河北省卫生厅医学科学研究课题计划项目 （）
