中国水产科学Issue(3)：637-645,9.DOI:10.3724/SP.J.1118.2014.00637
鱼类黑素皮质素受体（MCR）研究进展
Advances in fish melanocortin receptor family research
摘要
Abstract
The melanocortin receptor family, with seven transmembrane alpha-helixs, is a member of the smallest G-protein-coupled receptor and of great importance in chordate physiological function. The melanocortin receptor fam-ily has five subtypes (MC1R, MC2R, MC3R, MC4R and MC5R) in mammalian and tetrapod, with rather diverse func-tions. It has been confirmed that MCRs are involved in diverse number of physiological functions, including pigmenta-tion, steroidogenesis, energy homeostasis, inflammation and sexual function. In recent years, fish MCRs have gained more and more concern of researchers. Different MCR subtypes have been cloned and analyzed in several fish species. The MCRs of fish, the earliest vertebrates in evolution, is highly conserved compared with mammalian in molecular characterization and physiology fuction. Meanwhile they have some special features of their own. Thorough research on MCRs will contribute to our understanding of vertebrate MCRs evolution and its regulation functions in fish physiology. To facilitate the study on MCRs, we provide a review about clone, molecular characterization, pharmacology and phys-iological function of fish melanocortin receptors and highlight progress made in these areas.关键词
黑素皮质素受体(MCR)/鱼类/药理学/生物功能Key words
melanocortin receptors (MCR)/fish/pharmacology/biological function分类
农业科技引用本文复制引用
董晶晶,谢骏,习丙文..鱼类黑素皮质素受体（MCR）研究进展[J].中国水产科学,2014,(3):637-645,9.基金项目
现代农业产业技术体系建设专项资金资助项目(CARS-46-10) （CARS-46-10）
中央级公益性科研院所基本科研业务费专项资金项目(2013JBFM10) （2013JBFM10）
