摘要
Abstract
To investigate pulmonary function of pulmonary arterial hypertension(PAH) and interstitial lung disease(ILD) associated with connective tissue disease(CTD).Methods:Analyzed pulmonary function of 110 cases with CTD, including total lung capacity(TLC),forced vital capacity(FVC),forced expiratory volume in one second(FEV1.0),forced expiratory volume in one second to forced vital capacity ratio(FEV1.0/FVC),diffusion capacity of the lung for carbon monoxide(DLCO),lung carbon monoxide diffusion coefficient(DLCO/VA).The subjects were divided into 4 groups:PAH group(26 cases),ILD group(35 cases),PAH group and ILD group(15 cases),CTD control group(34 cases).Results:Variance analysis of each index of pulmonary function,the differences in TLC,FVC,FEV1.0,DLCO,DLCO/VA were statistically significant(P<0.05).Multiple comparison analysis showed that,the differences in TLC,FVC,FEV1.0,DLCO,DLCO/VA between the PAH group and the control group were statistically significantly(P<0.05).The difference in group ILD and group PAH were not obvious.PAH combined with ILD group compared with ILD group,TLC and FVC were significantly different(P<0.05).Compared with the control group,the abnormal rate of Dlco was the highest.Conclusion:The main performance of patients with CTD lung involvement is diffusion barriers and restrictive ventilation dysfunction.Pulmonary function in PAH and ILD have no significant difference.When compared with ILD,restrictive ventilation dysfunction of ILD combined with PAH is more obvious.关键词
结缔组织病/肺功能/肺动脉高压/间质性肺病Key words
Connective tissue diseases/Pulmonary function/Pulmonary arterial hypertension/Interstitial lung disease
