摘要
Abstract
Objective:To explore the effect of loading dose of rosuvastatin and simvastatin on the occurrence of perioperative cTnI, hs-CRP and cardiovascular events of patients with acute coronary syndrome before percutaneous coronary intervention operation. Methods:68 patients with acute coronary syndrome were selected.They were randomly divided into the rosuvastatin group(30 mg rosuvastatin was given before coronary angiography) and the simvastatin group(30 mg simvastatin was given before coronary angiography) with 34 patients in each group.We observed the changes of cTnI,hs-CRP before and after PCI of the two groups,and the adverse cardiovascular events(MACE) rate at 30 days after operation and 6 months.Results:Compared with the simvastatin group,in the fluvastatin group,at 30 days after operation and 6 months,the incidence rate of MACE was lower;after PCI,myocardial injury rate was low;after PCI,inflammatory cytokines increased amplitude was small.Conclusion:For patients with acute coronary syndrome,compared with simvastatin,rosuvastatin had better anti-inflammatory effect and myocardial protection effect,at the same time,it can significantly reduce the incidence of MACE after PCI.关键词
瑞舒伐他汀/辛伐他汀/急性冠脉综合征/经皮冠脉介入治疗/心血管事件/cTnI/hs-CRPKey words
Rosuvastatin/Simvastatin/Acute coronary syndrome/Percutaneous coronary intervention/Cardiovascular events/cTnI/hs-CRP
