中国社区医师Issue(35)：133-136,4.DOI:10.3969/j.issn.1007-614x.2014.35.82
Beclin-1、Bcl-2、Bax在子宫内膜样腺癌中的表达及意义
Expression and significance of Beclin-1,Bcl-2,Bax in endometrial carcinoma
樊兰英 1徐松 2冯一中3
作者信息
- 1. 215300江苏省昆山市锦溪人民医院妇产科1
- 2. 215300江苏省昆山市第一人民医院病理科2
- 3. 215000苏州大学附属第二人民医院病理科3
- 折叠
摘要
Abstract
Objective:To explore the expression and significance of Beclin-1,Bcl-2,Bax in endometrial carcinoma.Methods:We detected the expression of Beclin-1,Bcl-2,Bax gene in tissue chip of 80 patients with endometrioid adenocarcinoma and 40 cases of normal endometrium by immunohistochemical S-P method,and analyzed the correlation between the three and the relation with clinical pathological characteristics.Results:①Bax and Bcl-2 were high expression in endometrioid adenocarcinoma,and Beclin-1 was low expression in endometrioid adenocarcinoma.The results suggested that the three might participate in the occurrence and development of endometrioid adenocarcinoma.②The expression of Beclin-1 and Bcl-2,Beclin-1 and Bax were negatively correlated.The results suggested that Bax and Bcl-2 could promote the occurrence and development of endometrial adenocarcinoma by inhibiting the expression of Beclin-1.③Expression of Beclin-1 and Bcl-2 was of certain correlation with clinical and pathological features of endometrioid adenocarcinoma.The positive expression of Beclin-1 was closely related with the degree of tumor differentiation and TNM stage.It could be used as reference index of evaluating prognosis.Conclusion:Beclin-1,Bcl-2 and Bax has different levels of expression in endometrioid adenocarcinoma,and has important clinical significance.关键词
子宫内膜样腺癌/Beclin-1/Bcl-2/Bax/免疫组织化学Key words
Endometrial carcinoma/Beclin-1/Bcl-2/Bax/Immunohistochemistry引用本文复制引用
樊兰英,徐松,冯一中..Beclin-1、Bcl-2、Bax在子宫内膜样腺癌中的表达及意义[J].中国社区医师,2014,(35):133-136,4.
