摘要
Abstract
Objective:To explore the clinical effect of aripiprazole orally disintegrating tablets in the improvement of women's weight,prolactin increase caused by sulpiride,risperidone,olanzapine.Methods:60 cases of weight gain and hyperprolactinemic patients caused by sulpiride,risperidone,olanzapine were selected.All patients maintained antipsychotic drug treatment scheme of the original.According to the random number table,they were divided into the aripiprazole orally disintegrating tablets group(observation group) with 30 cases and the placebo group(control group) with 30 cases.After 12 weeks of treatment,we measured body mass index patients(BMI) changes and prolactin(PRI) level.At the same time,we evaluated the adverse reactions of aripiprazole orally disintegrating tablets treatment using side effects scale(TESS).Results:Compared with the control group,after treatment,BMI and PRL of the observation group was decreased significantly,and the difference was statistically significant(P<0.01).In the observation group,the total efficiency was 93.33%;in the control group,the total efficiency was 76.67%;the difference was statistically significant(P<0.05).In the observation group,the TESS score was (5.12+1.12);the control group was (4.98+1.08);there was no significant difference(P>0.05).Conclusion:Aripiprazole orally disintegrating tablets can effectively improve the women's weight,prolactin increase caused by sulpiride,risperidone,olanzapine,and it is safe and reliable.It is worthy of clinical application and promotion.关键词
阿立哌唑口腔崩解片/利培酮/舒必利/奥氮平Key words
Aripiprazole orally disintegrating tablets/Risperidone,Sulpiride,Olanzapine
