中国社区医师Issue(7)：37-38,39,3.DOI:10.3969/j.issn.1007-614x.2015.7.21
不同免疫抑制剂治疗甲状腺相关眼病的疗效分析
Analysis of therapeutic effects of different immunosuppressive treatment for thyroid associated ophthalmopathy
梁怡 1齐刚 1李颖菊1
作者信息
- 1. 441000湖北医药学院附属襄阳医院内分泌科 湖北省襄阳市
- 折叠
摘要
Abstract
Objective:To compare the therapeutic effects and safety of different immunosuppressive treatment for thyroid associated ophthalmopathy.Methods:86 cases of patients with thyroid associated ophthalmopathy were randomly divided into 3 groups:A group was treated with glucocorticoid(26 cases);B group was treated with methotrexate(31 cases);C group was treated with leflunomide(29 cases).The treatment course was 12 weeks.Before and after treatment,we observed the change of integral value,and compared the clinical efficacy and incidence of adverse reaction of the three groups.Results:At the end of the 12 week, compared with that before treatment,the integral value of integral thyroid associated ophthalmopathy of the three groups were decreased,and the difference was statistically significant(P<0.05).The decline from large to small in turn was leflunomide, methotrexate and corticosteroids.The incidence of adverse reaction:glucocorticoid group was 34.6% ,methotrexate group was 12.9% ,leflunomide group was 10.3% .Conclusion:The curative effect of leflunomide in the treatment of TAO as a immune inhibitors was superior to glucocorticoids and methotrexate;the adverse reaction was small;the efficacy of methotrexate in the treatment of thyroid associated ophthalmopathy as a immune inhibitors was similar with glucocorticoid;the adverse reaction was less;patient tolerance was good.关键词
甲状腺相关眼病/免疫抑制剂/来氟米特/甲氨蝶呤Key words
Thyroid associated ophthalmopathy/Immune inhibitors/Leflunomide/Methotrexate引用本文复制引用
梁怡,齐刚,李颖菊..不同免疫抑制剂治疗甲状腺相关眼病的疗效分析[J].中国社区医师,2015,(7):37-38,39,3.
