摘要
Abstract
Objective:To explore the effect of metformin combined with marvelon on the sex hormone and metabolism in patients with polycystic ovary syndrome.Methods:40 patients with PCOS were selected.They were randomly divided into the simple marvelon(A) group of 20 cases and combination with metformin(B) group of 20 cases.We compared the level of sex hormone and metabolism before and after treatment.Results:Compared with before treatment,after treatment,PRL,FSH,LH and T levels of two groups were reduced,while the level of E2 was increased(P<0.05),and the improvement of B group was superior than A group(P<0.05).After treatment,the FIns,HOMA-IR and HOMA-beta of B group were decreased compared with those before treatment(P<0.05).The TC,TG,HDL-C and LDL-C of two groups were all decreased,but there was significant difference only between TG and LDL-C(P<0.05).Conclusion:Metformin combined with marvelon can reduce the level of sex hormone,and regulate glucose and lipid metabolism.The effect was better than the single drug therapy with marvelon.关键词
二甲双胍/妈富隆/多囊卵巢综合征/性激素Key words
Metformin/Marvelon/Polycystic ovary syndrome/Sex hormone
