中国实验动物学报Issue(2)：32-35,4.DOI:10.3969/j.issn.1005-4847.2014.02.007
初步探讨鸟嘌呤核苷、姜黄素对 AD 双转基因小鼠学习记忆的影响
Preliminary discussion on the effects of guanosine, curcumin on learning and memory in AD double transgenic mice
摘要
Abstract
Objective Using Morris water maze test to evaluate the effects of guanosine and curcumin on cognitive function of APPswe/PS1dE9 double transgenic mice .Methods 3-month old APPswe/PS1dE9 dtg mice were randomly di-vided into model group , donepezil HCL group , guanosine group , curcumin group , curcumin and guanosine group ( n=12), with age-matched Wild C57BL/6J mice of the same genetic background as normal control group .Medication was giv-en once a day for 1 month.Using Morris water maze to test the spatial learning and memory ability of mice .Results Guanosine and curcumin could improve spatial learning and memory disorders of AD mice , particularly in the group of cur-cumin.Conclusion Guanosine and curcumin improve the cognitive ability of APPswe /PS1dE9 double transgenic mice with early cognitive impairment .关键词
鸟嘌呤核苷/姜黄素/APPswe/PS1dE9双转基因小鼠/行为学Key words
Guanosine/Curcumin/APPswe/PS1dE9 double transgenic mice/Ethology分类
生物科学引用本文复制引用
樊惠,冯慧利,党惠子,陈晓培,任映,杨金铎,王蓬文..初步探讨鸟嘌呤核苷、姜黄素对 AD 双转基因小鼠学习记忆的影响[J].中国实验动物学报,2014,(2):32-35,4.基金项目
国家自然基金面上资助项目（No．81073076）；教育部高等学校创新团队（IRT0810）。 （）
