中国实验动物学报Issue(2)：40-44,5.DOI:10.3969/j.issn.1005-4847.2014.02.009
慢性束缚应激对 SD 和 Wistar 大鼠学习记忆能力的影响
Effects of chronic restraint stress on learning and memory in SD and Wistar rats
摘要
Abstract
Objective To investigate the effects of chronic restraint stress on learning and memory in Wistar and Sprague-Dawley (SD) rats.Methods Healthy adult male Wistar rats (n=6) and Sprague-Dawley rats (n=6) were subjected to restraint stress 10 h daily for 28 days.After that, all rats were tested for recognition memory by novel object recognition test , and spatial memory and working memory by Morris water maze test .Results After restraint for 10 h daily for 28 days, the restraint rats of the two strains demonstrated lower discrimination index (DI)than the control group, but on-ly SD rats showed significant difference ( P<0.05 ) .The restraint SD rats showed higher escape latency than the control rats, and on the 5th day the difference became significant (P<0.05), and there was no significant difference between Wistar restraint and control rats .The working memory test showed that restraint SD rats exibited longer escape latency than the control rats (P<0.05), while Wistar rats didn’t show significant difference between the two groups .Conclusions The results of this study demonstrate that the impairments of learning and memory in SD rats subjected to restraint 10 hour per day for 28 days are more serious than that in the Wistar rats .Therefore , SD rats may be a better choice as an animal model to study the effects of chronic restraint stress on learning and memory impairment .关键词
Sprague-Dawley大鼠/Wistar大鼠/束缚应激/新物体识别/水迷宫Key words
Wistar rat/Sprague-Dawley rat/Restraint stress/Novel-object recognition test/Morris water maze test/Spatial memory/Working memory分类
生物科学引用本文复制引用
王逸,卢聪,宋广青,陈怡西,武宏伟,王琼,曲丽娜,李莹辉,刘新民..慢性束缚应激对 SD 和 Wistar 大鼠学习记忆能力的影响[J].中国实验动物学报,2014,(2):40-44,5.基金项目
人参益智药效与基因／蛋白表达谱关联规律合作研究（2011DFA32730），模拟失重认知功能受损动物模型的建立（SMFA10K01），中长期航天飞行所致应激损伤评价与防护关键技术研究 （）
