中国实验动物学报Issue(2)：66-69,4.DOI:10.3969/j.issn.1005-4847.2014.02.015
七个中药复方对小鼠止咳化痰作用的对比实验
Experimental comparison of the antitussive and expectorant effects of seven traditional Chinese medicine compounds in mice
摘要
Abstract
Objective In order to screen effective traditional Chinese medicine compounds to prevent and control porcine respiratory disease syndrome ( PRDC) , seven compound preparations of traditional Chinese medicine were tested and to analyze their antitussive and expectorant effects in mice .Methods Two hundred 6-week old ICR mice ( male∶fe-male=1∶1) were used in this study .Dextromethorphan and ammonium chloride were used as positive control drugs , and physiological saline was used as blank control .The antitussive and expectorant effects of the seven Chinese medicine com-pounds (groups 1, 2, 3, 4, 5, 6, 7) were observed by ammonia-induced cough model and tracheal phenol red secretion method in mice .Results The results showed that compounds 7 and 5 significantly prolonged the cough incubation period (P <0.05), and reduced the cough times within 5 min (P <0.05).Except for the group 4, tracheal phenol red excre-tion in the other groups was significantly lower than that of blank control group (P <0.05), and phenol red excretion in the mice of groups 7, 5 and ammonium chloride group was significantly lower than that in other treatment groups ( P <0.05).Conclusions The Chinese medicine compounds 5 and 7 show most evident expectorant effects , and worthy of fur-ther validation of them as a drug in the treatment of porcine respiratory disease syndrome .关键词
中药复方/止咳化痰/浓氨水引咳法/气管段酚红分泌法/小鼠Key words
Traditional Chinese medicine compound/Antitussive and expectorant/Ammonia induced cough mod-el/Tracheal phenol red secretion method/Mice分类
生物科学引用本文复制引用
张晓菊,吴媛,蒋春燕,张超颖,兰新财..七个中药复方对小鼠止咳化痰作用的对比实验[J].中国实验动物学报,2014,(2):66-69,4.基金项目
浙江省科技厅公益技术研究农业项目（2011C22033）。 （）
