中国实验动物学报Issue(4)：77-80,4.DOI:10.3969/j.issn.1005-4847.2014.04.017
宫内和出生后早期发育环境对成年期糖代谢影响的中枢调控作用机制
Central neuroregulatory machanisms between early life environment and glucose metabolism in adulthood
摘要
Abstract
Traditionally it has been widely accepted that our genes together with adult lifestyle factors determine our risk of developing noncommunicable diseases such as type 2 diabetes mellitus ,cardiovascular disease and obesity in lat-er life.Currently, there is substantial evidence that the early life environment plays a key role in determining our suscepti -ble to such diseases in later life .As an increased focus on the understanding of central insulin resistance , central nerve sys-tem plays an extremely important role in regulating the peripheral glucose homeostasis .Substantial studies have indicated that it may be regulated by epigenetic mechanisms .Epigenetics can be defined as the study of heritable changes in gene ex-pression that do not involve alterations in the DNA sequence .Epigenetic processes play a central role in regulating tissue specific gene expression and hence alterations in these processes can induce long -term changes in gene expression and me-tabolism which persist throughout the lifecourse .This review will focus on the epigenetic machanisms of central neuroregula-tion between early life environment and glucose metabolism in adulthood .关键词
中枢调控/早期发育环境/糖代谢Key words
Glucose metabolism/Central nervous system/Central neuroregulation分类
生物科学引用本文复制引用
郑佳,肖新华..宫内和出生后早期发育环境对成年期糖代谢影响的中枢调控作用机制[J].中国实验动物学报,2014,(4):77-80,4.基金项目
国家自然科学基金（81170736）；国家临床重点专科建设项目。 （）
