中国实验动物学报Issue(5)：87-94,8.DOI:10.3969/j.issn.1005-4847.2014.05.020
丙型肝炎病毒感染实验动物模型的研究进展
Advances in research on experimental animal models of HCV infection
摘要
Abstract
Hepatitis C virus ( HCV) is a leading cause of chronic hepatitis, cirrhosis, and hepatocellular carcino-ma in humans.Due to the lack of suitable experimental animal models for HCV infection, the development of more effective treatment of HCV infection and vaccines has been delayed.Chimpanzee is the best experimental animal model for the re-search of hepatitis C virus ( HCV) infection.However, because of its limited in resource, expensive in breeding, and difference in clinical symptoms, thus developing new experimental animal models for HCV-related basic and applied re-search is imminent.In recent years, as a surrogate animal model, the development of rodent model and other models has been achieved a lot of progress.Using such as genetically modified experimental techniques, those surrogate animals were infected with HCV in vivo and were successfully applied to research in several areas.In this review, we will focus on the a-chieved progress in naturally infected animal model and transgenic surrogate experimental models, and their advantage and limitation in usage in study on the pathogenetic mechanism of infection, drug evaluation and development of vaccines, and will also discuss the future direction of development of experimental animal models for research of infection with HCV.关键词
丙型肝炎病毒/自然感染的动物模型/替代实验动物模型/啮齿类动物Key words
Hepatitis C virus/Naturally infected animal models/Surrogate animal models/Rodents分类
生物科学引用本文复制引用
姜晨晨,彭宗根..丙型肝炎病毒感染实验动物模型的研究进展[J].中国实验动物学报,2014,(5):87-94,8.基金项目
国家自然科学基金委优秀青年科学基金（81322050）；教育部新世纪优秀人才项目（ NCET-12-0072）；北京市科技新星项目 （）
