中国实验动物学报Issue(2)：124-126,3.DOI:10.3969/j.issn.1005-4847.2015.02.004
搏动型心室辅助装置大动物模型的建立
Establishment of a sheep model of pulsatile ventricular assist device
摘要
Abstract
Objective To establish a large animal ( sheep) model to serve the experiments of domestic pulsatile ventricular assist device.Methods Three small-tail Han-sheep were anesthetized and the vein access and artery access were achieved.The cardiopulmonary bypass was established through left thoracotomy.Ventricular fibrillation was induced. An hole was made in the apex of left ventricle and the apex cannulation was sutured to it.The aortic cannulation was su-tured to the descending aorta.The two cannulations were connected to the domestic pulsatile ventricular assist device ( DP-VAD) and the driver was turned on.The working of DPVAD and the conditions of the animals were observed.Results The DPVAD worked well and uni-directional blood flow was driven by positive and negative pressure.The left ventricle was unloaded and the blood pressure was raised up.Conclusion The establishment of sheep model of pulsatile ventrieular as-sist device may play important role for the research and development of DPVAD in our country.关键词
心室辅助装置/羊/动物模型Key words
Ventricular assist device/Sheep/Animal model分类
生物科学引用本文复制引用
叶亮,李铁岩,曹浩,张治国,卢蓉,丁海燕,范慧敏..搏动型心室辅助装置大动物模型的建立[J].中国实验动物学报,2015,(2):124-126,3.基金项目
上海领军人才（2012-053）；上海市浦东新区卫生系统领先人才（ Grant No．PWR12011-01）；上海市医学重点专科心脏外科（ZK2012A27）；上海市科委重点项目（13411951402）；上海市浦东新区卫生系统重点学科群（Grant No．PWZxq2014-01）。 （）
