中国实验动物学报Issue(3)：321-326,6.DOI:10.3969/j.issn.1005-4847.2015.03.019
抑郁症动物模型及评价方法研究进展
Research progress on animal models of depression and their evaluation methods
摘要
Abstract
Depression, a seriously harmful disease to peoples ’ physical and mental health , is prevailing world-wide.But the etiology and pathological mechanism is still not fully uncovered .With the development of social economy and the pace of life speeding up , increasing pressure and vulnerable emotion cause depression incidence increased rapidly .For the further research on depression , study of depression mechanism and antidepressant drugs highly depends on effective ani -mal models .The degree of similarity of animal models to human disease status and the accuracy and reliability of evaluation methods of animal models directly influence the value of the resuts of experiments .In this article we introduce the common-ly used animal models of depression , the evaluation indicators at organism , organ, and molecular levels , and to provide theoretical references for the further studies on depression .关键词
抑郁症/动物模型/行为学/生化指标Key words
Depression/Animal model/Behavior/Biochemical criteria/Evaluation methods分类
生物科学引用本文复制引用
薛涛,邬丽莎,刘新民,王琼..抑郁症动物模型及评价方法研究进展[J].中国实验动物学报,2015,(3):321-326,6.基金项目
全军医药卫生“十二五”科研项目（BWS11J052）；人因工程重点实验室开放基金资助项目（HF2012－K－06）；四川省科技厅－泸州市人民政府－泸州医学院联合科研资金项目［14JC01323－LH50］． （）
