中国比较医学杂志Issue(9)：14-17,4.DOI:10.3969/j.issn.1671.7856.2014.009.004
喜炎平注射液对比格犬心电图的影响
Effects of Xi Yanping injection on electrocardiogram of Beagle dogs
摘要
Abstract
Objective To study the effect of Xi Yanping injection on electrocardiogram in Beagle dogs.Methods 24 Beagle dogs were divided into negative control group (0 mg/kg), low-dose group (15 mg/kg), middle-dose group (75 mg/kg), high-dose group (250 mg/kg).Each group consist of 3 animals/sex/group, all animals were administrated by intravenous drip at 20 mL/kg once a day.Administration period was 28-days with 14-days recovery phase.Animals LeadⅡelectrocardiogram ( ECG) was measured during quanrantine, administration and recovery phase.The following parameters included heart rate, P -Rinterval, Q -T interval, P, Q, RS wave amplitude and ST and T wave amplitude were determined, serum biochemical parameters were measured to evaluate the effect on main organs.Results All parameters of quarantine period were fell in the normal limit.After the first administration, heart rate decrease was found in low dose group and P-Rinterval prolongation was found in high dose group.No abnormal was found in dose metaphase,end of dose stage and recovery stage.Conclusion Xi Yanping injection had no obvious influence on ECG of Beagle dog.关键词
喜炎平注射液/比格犬/心电图Key words
Xi Yanping injection/Beagle dogs/Electrocardiogram ( ECG)分类
医药卫生引用本文复制引用
齐卫红,王超,李欣,张琳,刘运强,李伟..喜炎平注射液对比格犬心电图的影响[J].中国比较医学杂志,2014,(9):14-17,4.基金项目
国家“重大新药创制”科技重大项目（2012ZX09302001）。 （）
